Maes M, Maes L, Suy E
Psychiatric Center St. Jozef, Munsterbilzen, Belgium.
Psychoneuroendocrinology. 1990;15(1):29-37. doi: 10.1016/0306-4530(90)90044-a.
The dexamethasone suppression test (DST), the thyrotropin releasing hormone (TRH) test, and the ratio of plasma L-tryptophan to competing amino acids (L-TRP/CAA) were studied in relation to the 21 items of the Hamilton Depression Rating Scale (HDRS) in 123 depressed patients categorized according to DSM-III. The relationships between the biological data and the items or item clusters of the HDRS were assessed by multivariate analyses. The psychopathological correlates of increased post-dexamethasone cortisol and decreased thyroid stimulating hormone (TSH) responsivity to TRH were middle and delayed insomnia and weight loss. The symptom correlates of decreased availability of L-TRP to the brain were psychic anxiety, depersonalization, obsessions and paranoid symptoms. Core depressive symptoms, i.e. depression, loss of interest, feelings of guilt and suicidal thoughts, were not related to the biological markers.
对123例根据《精神疾病诊断与统计手册》第三版（DSM-III）分类的抑郁症患者，研究了地塞米松抑制试验（DST）、促甲状腺激素释放激素（TRH）试验以及血浆L-色氨酸与竞争性氨基酸的比值（L-TRP/CAA）与汉密尔顿抑郁量表（HDRS）21项指标的关系。通过多变量分析评估生物学数据与HDRS各项或项目集群之间的关系。地塞米松给药后皮质醇升高和促甲状腺激素（TSH）对TRH反应性降低的精神病理学相关因素是中度和延迟性失眠以及体重减轻。大脑中L-TRP可用性降低的症状相关因素是精神性焦虑、人格解体、强迫观念和偏执症状。核心抑郁症状，即抑郁、兴趣丧失、内疚感和自杀念头，与生物学标志物无关。
