Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, Exporo 483, Yuseong-gu, Daejeon 305-811, Republic of Korea.
Food Chem Toxicol. 2011 Apr;49(4):829-37. doi: 10.1016/j.fct.2010.12.004. Epub 2010 Dec 9.
Asthma is a chronic immune inflammatory disease characterized by variable airflow obstruction. The present study was undertaken to assess the effects of an Angelica dahurica Bentham et Hooker ethanolic extract (AD) on airway inflammation in an ovalbumin (OVA)-induced airway inflammation model. Mice that received AD displayed significantly lower airway eosinophilia, cytokine levels, including interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-alpha levels, mucus production and immunoglobulin (Ig)E, compared with OVA-induced mice. In our experiments, AD treatment reduced airway inflammation and suppressed oxidative stress in the OVA-induced asthma model, partly via induction of heme oxygenase (HO)-1. The effects of AD on OVA-induced HO-1 induction were partially reversed by the HO-1 inhibitor, tin protoporphyrin (SnPP). Our results clearly indicate that AD is a suppressor of airway allergic inflammation, and may thus be effectively used as an anti-inflammatory drug in the treatment of asthma.
哮喘是一种慢性免疫炎症性疾病，其特征是气流阻塞的可变性。本研究旨在评估当归 Bentham et Hooker 乙醇提取物 (AD) 对卵清蛋白 (OVA) 诱导的气道炎症模型中气道炎症的影响。与 OVA 诱导的小鼠相比，接受 AD 的小鼠气道嗜酸性粒细胞、细胞因子水平（包括白细胞介素 (IL)-4、IL-5 和肿瘤坏死因子 (TNF)-α 水平）、黏液产生和免疫球蛋白 (Ig)E 显著降低。在我们的实验中，AD 治疗可减轻 OVA 诱导的哮喘模型中的气道炎症并抑制氧化应激，部分是通过诱导血红素加氧酶 (HO)-1。AD 对 OVA 诱导的 HO-1 诱导的作用部分被 HO-1 抑制剂锡原卟啉 (SnPP) 逆转。我们的研究结果清楚地表明，AD 是气道过敏炎症的抑制剂，因此可有效用作哮喘治疗的抗炎药物。
