Department of Dermatology, University of Alabama, Birmingham, AL 35294, USA.
Arch Biochem Biophys. 2011 Apr 15;508(2):144-51. doi: 10.1016/j.abb.2010.12.007. Epub 2010 Dec 11.
The skin is the largest organ of the body that produces a flexible and self-repairing barrier and protects the body from most common potentially harmful physical, environmental, and biological insults. Solar ultraviolet (UV) radiation is one of the major environmental insults to the skin and causes multi-tiered cellular and molecular events eventually leading to skin cancer. The past decade has seen a surge in the incidence of skin cancer due to changes in life style patterns that have led to a significant increase in the amount of UV radiation that people receive. Reducing excessive exposure to UV radiation is desirable; nevertheless this approach is not easy to implement. Therefore, there is an urgent need to develop novel strategies to reduce the adverse biological effects of UV radiation on the skin. A wide variety of natural agents have been reported to possess substantial skin photoprotective effects. Numerous preclinical and clinical studies have elucidated that natural agents act by several cellular and molecular mechanisms to delay or prevent skin cancer. In this review article, we have summarized and discussed some of the selected natural agents for skin photoprotection.
皮肤是人体最大的器官，它能产生灵活的、自我修复的屏障，保护身体免受大多数常见的、潜在有害的物理、环境和生物侵害。太阳紫外线（UV）辐射是皮肤的主要环境侵害之一，它会引发多层次的细胞和分子事件，最终导致皮肤癌。由于生活方式的改变，人们接受的紫外线辐射量显著增加，过去十年皮肤癌的发病率呈上升趋势。减少过度暴露于紫外线辐射是理想的；然而，这种方法并不容易实施。因此，迫切需要开发新的策略来减少紫外线辐射对皮肤的不良生物学影响。据报道，有多种天然物质具有显著的皮肤光保护作用。大量的临床前和临床研究已经阐明，天然物质通过几种细胞和分子机制来延迟或预防皮肤癌。在这篇综述文章中，我们总结和讨论了一些用于皮肤光保护的天然物质。
