特定语言障碍儿童的中央言语处理缺陷的证据：T 复合体。
Evidence of deficient central speech processing in children with specific language impairment: the T-complex.
机构信息
The Graduate Center, City University of New York, NY 10016, USA.
出版信息
Clin Neurophysiol. 2011 Jun;122(6):1137-55. doi: 10.1016/j.clinph.2010.10.046. Epub 2010 Dec 13.
OBJECTIVE
This paper examined neurophysiological correlates of speech in children with language impairment (LI) and typical language development (TLD) across four experiments using different speech stimuli and tasks.
METHODS
The T-complex event-related potential (ERP) components and other ERP components (e.g., mismatch negativity [MMN]; N400) were examined. A subset of the children participated in more than one of the experiments.
RESULTS
73% of the children with LI had poor T-complex measures compared to only 13% of children with TLD. The T-complex measures were more comparable, in terms of indicating typical versus deviant processing, to neurophysiological measures of language processing, such as lexical discrimination, than to other measures of auditory and speech processing, such as the MMN. Only one LI child showed no poor measures and 64% showed three or more poor neurophysiological measures. However, 50% of children with TLD showed no poor neurophysiological measures, and 82% of the TLD children showed no more than two poor measures.
CONCLUSIONS
These results suggest that poor auditory processing, as measured by the T-complex, is a marker for LI and that multiple deficits serve to mark LI.
SIGNIFICANCE
The T-complex measures, indexing secondary auditory cortex, reflect an important aspect of processing in speech and language development.
目的
本文通过四个实验，使用不同的语音刺激和任务，研究了语言障碍（LI）和典型语言发展（TLD）儿童的语音神经生理相关性。
方法
检测了 T 复合事件相关电位（ERP）成分和其他 ERP 成分（如失匹配负波[MMN]；N400）。一部分儿童参与了不止一个实验。
结果
与仅有 13%的 TLD 儿童相比，73%的 LI 儿童的 T 复合测量值较差。在指示典型与偏差处理方面，T 复合测量值与语言处理的神经生理测量值（如词汇辨别）更相似，而与其他听觉和语音处理测量值（如 MMN）不那么相似。只有一名 LI 儿童没有较差的测量值，而 64%的儿童有三个或更多较差的神经生理测量值。然而，50%的 TLD 儿童没有较差的神经生理测量值，而 82%的 TLD 儿童没有超过两个较差的测量值。
结论
这些结果表明，T 复合测量的较差听觉处理是 LI 的标志，而多个缺陷有助于标记 LI。
意义
T 复合测量值，索引次要听觉皮层，反映了言语和语言发展中处理的一个重要方面。
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