mTOR and its link to the picture of Dorian Gray - re-activation of mTOR promotes aging.
作者信息
Wesierska-Gadek Józefa
机构信息
Cell Cycle Regulation Group, Div., Institute of Cancer Research, Department of Medicine, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. Jozefa.Gadek‐
出版信息
Aging (Albany NY). 2010 Dec;2(12):892-3. doi: 10.18632/aging.100240.
Abstract
摘要
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本文引用的文献
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DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence.DNA损伤剂和p53不会在静止细胞中引起衰老，而mTOR的连续重新激活与细胞转变为衰老相关。
Aging (Albany NY). 2010 Dec;2(12):924-35. doi: 10.18632/aging.100265.
2
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway.p53诱导的衰老与静止之间的选择部分由mTOR信号通路决定。
Aging (Albany NY). 2010 Jun;2(6):344-52. doi: 10.18632/aging.100160.
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Paradoxical suppression of cellular senescence by p53.p53对细胞衰老的反常抑制
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p53 and metabolism.p53与新陈代谢
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p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence.p53 异构体 Delta133p53 和 p53β 是复制性细胞衰老的内源性调节因子。
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