Dulic Vjekoslav
Institut de Génétique Moléculaire, Montpellier, France.
Methods Mol Biol. 2013;965:15-35. doi: 10.1007/978-1-62703-239-1_2.
The senescence program is activated in response to diverse stress stimuli potentially compromising genetic stability and leads to an irreversible cell cycle arrest. The mTOR pathway plays a crucial role in the regulation of cell metabolism and cellular growth. The goal of this chapter is to present evidence linking these two processes, which have one common regulator-the tumor suppressor p53. While the role of mTOR in senescence is still controversial, recent papers have shed new light onto this issue. This review, far from being exhaustive given the complexity of the field, will hopefully stimulate further research in this domain, whose relevance for ageing is becoming increasingly documented.
衰老程序会因各种可能损害基因稳定性的应激刺激而被激活，并导致不可逆的细胞周期停滞。mTOR通路在细胞代谢和细胞生长的调节中起着关键作用。本章的目的是提供证据，将这两个过程联系起来，它们有一个共同的调节因子——肿瘤抑制因子p53。虽然mTOR在衰老中的作用仍存在争议，但最近的论文为这个问题提供了新的线索。鉴于该领域的复杂性，本综述远非详尽无遗，希望能激发该领域的进一步研究，其与衰老的相关性正越来越多地得到文献记载。
