Weber Rainer, Sabin Caroline, Reiss Peter, de Wit Stephane, Worm Signe W, Law Matthew, Dabis Francois, D'Arminio Monforte Antonella, Fontas Eric, El-Sadr Wafaa, Kirk Ole, Rickenbach Martin, Phillips Andrew, Ledergerber Bruno, Lundgren Jens
Antivir Ther. 2010;15(8):1077-86. doi: 10.3851/IMP1681.
Data on a link between HCV or HBV infection and the development of cardiovascular disease among HIV-negative and HIV-positive individuals are conflicting. We sought to investigate the association between HBV or HCV infection and myocardial infarction in HIV-infected individuals.
The prospective observational database of the D:A:D collaboration of 11 cohorts of HIV-infected individuals, including 212 clinics in Europe, the United States and Australia was used. Multivariate Poisson regression was used to assess the effect of HCV or HBV infection on the development of myocardial infarction after adjustment for potential confounders, including cardiovascular risk factors, diabetes mellitus and exposure to antiretroviral therapy.
Of 33,347 individuals, 517 developed a myocardial infarction over 157,912 person-years, with an event rate of 3.3 events/1,000 person-years (95% confidence interval [CI] 3.0-3.6). Event rates (95% CIs) per 1,000 person-years in those who were HCV-seronegative and HCV-seropositive were 3.3 (3.0-3.7) and 2.7 (2.2-3.3), respectively, and for those who were HBV-seronegative, had inactive infection or had active infection were 3.2 (2.8-3.5), 4.2 (3.1-5.2) and 2.8 (1.8-3.9), respectively. After adjustment, there was no association between HCV seropositivity (rate ratio 0.86 [95% CI 0.62-1.19]), inactive HBV infection (rate ratio 1.07 [95% CI 0.79-1.43]) or active HBV infection (rate ratio 0.78 [95% CI 0.52-1.15]) and the development of myocardial infarction.
We found no association between HBV or HCV coinfection and the development of myocardial infarction among HIV-infected individuals.
关于丙型肝炎病毒（HCV）或乙型肝炎病毒（HBV）感染与HIV阴性及HIV阳性个体心血管疾病发生之间联系的数据存在矛盾。我们试图研究HBV或HCV感染与HIV感染者心肌梗死之间的关联。
使用了D:A:D合作组织的前瞻性观察数据库，该数据库来自11个HIV感染者队列，包括欧洲、美国和澳大利亚的212家诊所。多变量泊松回归用于评估HCV或HBV感染对心肌梗死发生的影响，同时对潜在混杂因素进行了调整，这些因素包括心血管危险因素、糖尿病以及抗逆转录病毒治疗的暴露情况。
在33347名个体中，517人在157912人年的时间里发生了心肌梗死，事件发生率为3.3例/1000人年（95%置信区间[CI] 3.0 - 3.6）。HCV血清学阴性和HCV血清学阳性者每1000人年的事件发生率（95% CI）分别为3.3（3.0 - 3.7）和2.7（2.2 - 3.3），HBV血清学阴性、感染处于非活动期或处于活动期者每1000人年的事件发生率分别为3.2（2.8 - 3.5）、4.2（3.1 - 5.2）和2.8（1.8 - 3.9）。调整后，HCV血清学阳性（率比0.86 [95% CI 0.62 - 1.19]）、HBV非活动期感染（率比1.07 [95% CI 0.79 - 1.43]）或HBV活动期感染（率比0.78 [95% CI 0.52 - 1.15]）与心肌梗死的发生之间均无关联。
我们发现HIV感染者中HBV或HCV合并感染与心肌梗死的发生之间无关联。
