Animal Bioscience and Biotechnology Laboratory, USDA-ARS, Beltsville, Maryland 20715, USA.
Pediatr Res. 2011 Apr;69(4):330-5. doi: 10.1203/PDR.0b013e31820a5b9c.
A study was conducted to validate the use of a quantitative magnetic resonance (QMR) device for measuring the body composition of infants and neonates weighing < 12 kg using the pig as a model. A total of 25 piglets weighing between 2 and 12 kg were studied. Body composition was assessed by QMR, dual-energy x-ray absorptiometry (DXA), and whole-body chemical analysis (CA) of carcass for lipid and water content. The precision, mean and SD of repeated measurements, of QMR to estimate fat mass (FM), lean mass (LM), and total body water (TBW) for five consecutive scans with reposition was 12.5, 32.0, and 36.0 g, respectively. QMR measures of FM, LM, and TBW were highly and significantly correlated with CA of carcass. In terms of accuracy, mean difference between QMR and CA (percent of mean value for CA), QMR overestimated FM by 40 g (4.7%), overestimated LM by 114.9 g (2.1%), and underestimated TBW by 134.6 g (3.1%). This study concludes that QMR provides precise and accurate measures of FM, LM, and TBW in piglet weighing up to 12 kg. These results suggest that QMR can provide valuable body composition data in longitudinal studies in infants.
一项研究旨在验证使用定量磁共振（QMR）设备测量体重<12kg 的婴儿和新生儿的身体成分，该研究以猪为模型。共有 25 头体重在 2 至 12kg 之间的仔猪参与了该研究。通过 QMR、双能 X 射线吸收法（DXA）和尸体的全身体化学分析（CA）测量脂质和水分含量来评估身体成分。在进行五次连续扫描并重新定位时，QMR 对脂肪量（FM）、瘦肉量（LM）和总身体水量（TBW）的重复测量的精度、平均值和标准差分别为 12.5、32.0 和 36.0g。QMR 对 FM、LM 和 TBW 的测量与 CA 高度显著相关。就准确性而言，QMR 与 CA 的平均差值（CA 平均值的百分比），QMR 高估了 FM 40g（4.7%），高估了 LM 114.9g（2.1%），低估了 TBW 134.6g（3.1%）。本研究得出结论，QMR 可以精确和准确地测量体重<12kg 的仔猪的 FM、LM 和 TBW。这些结果表明，QMR 可以在婴儿的纵向研究中提供有价值的身体成分数据。
