Erfelijkheidsleer en Microbiologie, Vrije Universiteit Brussel, Brussel, Belgium.
Archaea. 2010 Nov 30;2010:750457. doi: 10.1155/2010/750457.
Archaea possess a eukaryotic-type basal transcription apparatus that is regulated by bacteria-like transcription regulators. A universal and abundant family of transcription regulators are the bacterial/archaeal Lrp-like regulators. The Lrp family is one of the best studied regulator families in archaea, illustrated by investigations of proteins from the archaeal model organisms: Sulfolobus, Pyrococcus, Methanocaldococcus, and Halobacterium. These regulators are extremely versatile in their DNA-binding properties, response to effector molecules, and molecular regulatory mechanisms. Besides being involved in the regulation of the amino acid metabolism, they also regulate central metabolic processes. It appears that these regulatory proteins are also involved in large regulatory networks, because of hierarchical regulations and the possible combinatorial use of different Lrp-like proteins. Here, we discuss the recent developments in our understanding of this important class of regulators.
古菌拥有真核生物类型的基础转录装置，该装置受类似细菌的转录调节剂调控。一类普遍存在且丰富的转录调节剂是细菌/古菌 Lrp 样调节剂。Lrp 家族是古菌中研究得最好的调节剂家族之一，通过对古菌模式生物（如 Sulfolobus、Pyrococcus、Methanocaldococcus 和 Halobacterium）的蛋白质的研究可以说明这一点。这些调节剂在 DNA 结合特性、对效应分子的反应以及分子调节机制方面具有极高的多样性。除了参与氨基酸代谢的调节外，它们还调节中心代谢过程。似乎这些调节蛋白还参与了大型调节网络，因为存在分层调节和可能组合使用不同的 Lrp 样蛋白。在这里，我们讨论了我们对这一重要调节蛋白类别的理解的最新进展。
