阿尔茨海默病中的钙与神经发生
Calcium and neurogenesis in Alzheimer's disease.
作者信息
Wang Jun Ming, Sun Chenyou
机构信息
Department of Pathology, University of Mississippi Medical Center Jackson, MS, USA.
出版信息
Front Neurosci. 2010 Dec 2;4:194. doi: 10.3389/fnins.2010.00194. eCollection 2010.
Abstract
It was evidenced that impairment of calcium homeostasis is a potential mechanism in the development of Alzheimer's disease (AD). It remains, however, unclear how the calcium signaling are associated with in AD progression. Here we review recent studies to discuss the relationship among the signaling of intracellular calcium concentration, neurogenic activity, and AD progression. Analyzing these findings may provide new ideas to improve the neurogenic status in pathological processes in the aging brain.
摘要
有证据表明钙稳态受损是阿尔茨海默病（AD）发病的潜在机制。然而，钙信号在AD进展过程中的关联仍不清楚。在此，我们综述近期研究，以探讨细胞内钙浓度信号、神经发生活性和AD进展之间的关系。分析这些发现可能为改善衰老大脑病理过程中的神经发生状态提供新思路。
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