健康与疾病状态下人类红细胞的形状及生物力学特征
Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease.
作者信息
Diez-Silva Monica, Dao Ming, Han Jongyoon, Lim Chwee-Teck, Suresh Subra
出版信息
MRS Bull. 2010 May;35(5):382-388. doi: 10.1557/mrs2010.571.
Abstract
The biconcave shape and corresponding deformability of the human red blood cell (RBC) is an essential feature of its biological function. This feature of RBCs can be critically affected by genetic or acquired pathological conditions. In this review, we highlight new dynamic in vitro assays that explore various hereditary blood disorders and parasitic infectious diseases that cause disruption of RBC morphology and mechanics. In particular, recent advances in high-throughput microfluidic devices make it possible to sort/identify healthy and pathological human RBCs with different mechanobiological characteristics.
摘要
人类红细胞（RBC）的双凹形及其相应的可变形性是其生物学功能的一个基本特征。红细胞的这一特征会受到遗传或后天病理状况的严重影响。在本综述中，我们重点介绍了新的动态体外检测方法，这些方法可用于探究各种导致红细胞形态和力学破坏的遗传性血液疾病和寄生虫感染性疾病。特别是，高通量微流控设备的最新进展使得对具有不同机械生物学特征的健康和病理性人类红细胞进行分选/识别成为可能。
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本文引用的文献
1
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Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1289-94. doi: 10.1073/pnas.0910785107. Epub 2010 Jan 6.
2
Deformability limits of Plasmodium falciparum-infected red blood cells.恶性疟原虫感染的红细胞的变形能力极限。
Cell Microbiol. 2009 Sep;11(9):1340-53. doi: 10.1111/j.1462-5822.2009.01334.x. Epub 2009 Apr 30.
3
High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions.间日疟原虫感染的红细胞在微流控条件下具有高变形性。
J Infect Dis. 2009 Feb 1;199(3):445-50. doi: 10.1086/596048.
4
Hereditary spherocytosis.遗传性球形红细胞增多症
Lancet. 2008 Oct 18;372(9647):1411-26. doi: 10.1016/S0140-6736(08)61588-3.
5
Functional alteration of red blood cells by a megadalton protein of Plasmodium falciparum.恶性疟原虫的一种兆道尔顿蛋白对红细胞的功能改变
Blood. 2009 Jan 22;113(4):919-28. doi: 10.1182/blood-2008-05-157735. Epub 2008 Oct 2.
6
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7
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8
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Anal Chem. 2008 Mar 15;80(6):2204-11. doi: 10.1021/ac702283m. Epub 2008 Feb 15.
10
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