儿科精神药物联合使用
Pediatric psychotropic polypharmacy.
作者信息
Zonfrillo Mark R, Penn Joseph V, Leonard Henrietta L
出版信息
Psychiatry (Edgmont). 2005 Aug;2(8):14-9.
STUDY OBJECTIVE
This study was a literature review designed to assess the rates of psychotropic "polypharmacy" in the pediatric population. Psychotropic polypharmacy was defined as the practice of prescribing two or more medications (e.g. concomitant psychotropic medications) for one or more diagnosed psychiatric conditions and/or behavioral symptoms.
METHODS
A literature review of relevant articles pertaining to polypharmacy was completed using the Pub Med database from 1994 through April 2004 for pediatric populations under 18 years old.
RESULTS
Studies were reviewed from various pediatric settings. While the extent of polypharmacy varied from the different populations, all the studies comparing these rates across time showed an increase in this practice. The use of stimulants with another psychotropic medication was the most frequent combination.
CONCLUSIONS
There is limited information about the actual rates of psychotropic polypharmacy in the pediatric population. However, the data that are available demonstrate that this practice is on the rise. This is of specific concern due to the increase of adverse events with polypharmacy. The implications of polypharmacy, including efficacy and side effects, are generally unknown and may vary by specific combination. Therefore, these prescribing practices should be conducted with caution, and systematic research is needed.
研究目的
本研究是一项文献综述，旨在评估儿科人群中精神药物“联合用药”的比例。精神药物联合用药被定义为针对一种或多种已确诊的精神疾病和/或行为症状开具两种或更多药物（例如同时使用精神药物）的做法。
方法
利用1994年至2004年4月期间的Pub Med数据库，对与联合用药相关的儿科人群（18岁以下）的相关文章进行了文献综述。
结果
对来自不同儿科环境的研究进行了综述。虽然联合用药的程度因不同人群而异，但所有比较这些比例随时间变化的研究均显示这种做法有所增加。最常见的组合是将兴奋剂与另一种精神药物联用。
结论
关于儿科人群中精神药物联合用药的实际比例，信息有限。然而，现有数据表明这种做法正在增加。由于联合用药导致不良事件增多，这一点尤其令人担忧。联合用药的影响，包括疗效和副作用，通常尚不清楚，可能因具体组合而异。因此，这些处方做法应谨慎进行，并且需要进行系统研究。
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