Sun Jun
Gastroenterology & Hepatology Division, Department of Medicine, University of Rochester, Box 646, 601 Elmwood Avenue, Rochester, NY 14642, USA.
J Signal Transduct. 2010;2010:985132. doi: 10.1155/2010/985132. Epub 2010 Jul 20.
Inflammation plays a critical role in the development of cancer. Matrix Metalloproteinase (MMP) functions in the remodeling of the extracellular matrix that is integral for many normal and pathological processes such as morphogenesis, angiogenesis, tissue repair, and tumor invasion. The tissue inhibitor of metalloproteinases (TIMPs) family regulates the activity of multifunctional metalloproteinases. In this paper, we discuss the role and mechanism of MMP and TIMP in regulating inflammation responses in solid tumors. We discuss the mechanism of MMP and inflammation in melanoma, colon cancer, breast cancer, and prostate cancer. We highlight the roles of the TIMP-2 in modulating the proinflammatory NF-κB pathway in melanoma and lung caner cells. Based on the molecular mechanisms of TIMPs and MMPs in inflammation and cancer, we can design new strategies for cancer therapy.
炎症在癌症发展过程中起着关键作用。基质金属蛋白酶（MMP）在细胞外基质重塑中发挥作用，而细胞外基质重塑对于许多正常和病理过程（如形态发生、血管生成、组织修复和肿瘤侵袭）不可或缺。金属蛋白酶组织抑制剂（TIMP）家族调节多功能金属蛋白酶的活性。在本文中，我们讨论了MMP和TIMP在调节实体瘤炎症反应中的作用及机制。我们探讨了MMP与黑色素瘤、结肠癌、乳腺癌和前列腺癌中炎症的关系。我们着重强调了TIMP-2在调节黑色素瘤和肺癌细胞中促炎NF-κB途径方面的作用。基于TIMP和MMP在炎症及癌症中的分子机制，我们可以设计新的癌症治疗策略。
