尼日利亚东南部孕妇恶性疟原虫疟疾和艾滋病毒感染对出生体重的影响。
Effects of Maternal Plasmodium falciparum Malaria and HIV infection on Birth Weight in Southeastern Nigeria.
作者信息
Uneke Chigozie J, Duhlinska Dochka D, Ujam Treasure N
出版信息
Mcgill J Med. 2009 Nov 16;12(2):42.
The effects of malaria and HIV infection on birth weight were assessed among 300 women in childbirth in Southeastern Nigeria using standard techniques. Prevalence of maternal Plasmodium falciparum malaria infection was 16.0%. Individuals of younger age, primigravidae, anemic (with Hgb <11.0g/dl) and those who had never attended antenatal clinic (ANC) were more likely to have malaria infection. Prevalence of HIV infection was 3.6% and malaria prevalence was significantly higher among HIV-positive than HIV-negative women (37.5%, 95% CI, 4.0-71.0% versus 14.3%, 95% CI., 9.6-19.0%), (χ2 =13.3, P<0.05). Malaria-infected women had a significantly higher proportion of lBW babies than the uninfected (F-ratio=15.05, P<0.05). A higher proportion of low birth weight (lBW) was recorded among anemic women, primigravidae and those who never attended ANC. lBW babies were significantly higher among HIV-positive than HIV-negative women (25.0% vs 16.6%), (F-ratio=130.8, P<0.05). Malaria and HIV interventions via ANC are crucial for reduction of their adverse effects on pregnancy outcome.
采用标准技术，对尼日利亚东南部300名分娩妇女进行了疟疾和艾滋病毒感染对出生体重影响的评估。孕妇恶性疟原虫感染率为16.0%。年龄较小、初产妇、贫血（血红蛋白<11.0g/dl）以及从未参加过产前检查（ANC）的个体感染疟疾的可能性更大。艾滋病毒感染率为3.6%，艾滋病毒阳性妇女的疟疾患病率显著高于艾滋病毒阴性妇女（37.5%，95%CI，4.0 - 71.0%对14.3%，95%CI，9.6 - 19.0%），（χ2 = 13.3，P<0.05）。感染疟疾的妇女低体重儿比例显著高于未感染者（F值 = 15.05, P<0.05）。贫血妇女、初产妇以及从未参加过产前检查的妇女中低出生体重儿比例更高。艾滋病毒阳性妇女的低体重儿比例显著高于艾滋病毒阴性妇女（25.0%对16.6%），（F值 = 130.8, P<0.05）。通过产前检查进行疟疾和艾滋病毒干预对于减少它们对妊娠结局的不良影响至关重要。
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