Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Chem Commun (Camb). 2011 Feb 28;47(8):2348-50. doi: 10.1039/c0cc04319b. Epub 2010 Dec 10.
A simple, practical and efficient copper-catalyzed method for synthesis of aromatic carboxylic acids has been developed. The protocol uses inexpensive CuI/L-proline as the catalyst/ligand, and readily available aryl halides and malononitrile as the starting materials, and the corresponding aromatic carboxylic acids were obtained in moderate to good yields. The method is of tolerance towards functional groups in the substrates.
已开发出一种简单、实用、高效的铜催化合成芳香羧酸的方法。该方案使用廉价的 CuI/L-脯氨酸作为催化剂/配体，以及易得的芳基卤化物和丙二腈作为起始原料，可从中等至良好的产率得到相应的芳香羧酸。该方法对底物中的官能团具有耐受性。
