Goossen Lukas J, Manjolinho Filipe, Khan Bilal A, Rodríguez Nuria
Fachbereich Chemie, Technische Universitat Kaiserslautern, Erwin-Schroedinger-Strasse, D-67663 Kaiserslautern, Germany.
J Org Chem. 2009 Mar 20;74(6):2620-3. doi: 10.1021/jo802628z.
An effective protocol has been developed that allows the smooth protodecarboxylation of diversely functionalized aromatic carboxylic acids within 5-15 min. In the presence of at most 5 mol % of an inexpensive catalyst generated in situ from copper(I) oxide and 1,10-phenanthroline, even nonactivated benzoates were converted in high yields and with great preparative ease.
已开发出一种有效的方案，可使多种功能化的芳族羧酸在5至15分钟内顺利进行原脱羧反应。在由氧化亚铜和1,10-菲咯啉原位生成的至多5摩尔％的廉价催化剂存在下，即使是非活化的苯甲酸酯也能以高收率且非常易于制备的方式进行转化。
