Ribas Jonas, Schettini Antonio Pedro Mendes, Cavalcante Melissa de Sousa Melo
Universidade Federal do Amazonas, Brasil.
An Bras Dermatol. 2010 Sep-Oct;85(5):699-703. doi: 10.1590/s0365-05962010000500017.
Exogenous ochronosis is an infrequent dermatosis characterized as a dark blue hyperpigmentation localized where the causing agent was applied. It may be caused by the use of systemic medication such as antimalarials and by the use of topic substances such as phenol, resorcinol, benzene, or hydroquinone, which is a fenolic compound with depigmentation action, largely used in the treatment of melasma and other hyperpigmentation. The physiopathology of this process is not well clear up to this moment, and the therapeutic measures are not satisfactory either. Here we present four cases of female patients that developed hyperpigmentation on their faces after the use of hydroquinone containing compounds, characterized clinically and histological as ochronosi. We emphasize the possibility of exogenous ochronosis cases being misdiagnosed as a melasma treatment failure. We also emphasize the risks of the indiscriminated use of hydroquinone containing compounds, used, in many instances, without medical prescription.
外源性褐黄病是一种罕见的皮肤病，其特征为在涂抹致病剂的部位出现深蓝色色素沉着。它可能由使用抗疟药等全身性药物引起，也可能由使用苯酚、间苯二酚、苯或对苯二酚等局部物质引起，对苯二酚是一种具有色素脱失作用的酚类化合物，大量用于治疗黄褐斑和其他色素沉着。目前，这一过程的生理病理学尚未完全明确，治疗措施也不尽人意。在此，我们报告4例女性患者，她们在使用含对苯二酚的化合物后面部出现色素沉着，临床和组织学特征均为褐黄病。我们强调外源性褐黄病病例可能被误诊为黄褐斑治疗失败。我们还强调了在许多情况下无医嘱随意使用含对苯二酚化合物的风险。
