del Giorno Cecília, Fonseca Angela Maggio da, Bagnoli Vicente Renato, Assis Joserita Serrano de, Soares José Maria, Baracat Edmund Chada
departamento de Obstetrícia e Ginecologia da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Rev Assoc Med Bras (1992). 2010 Sep-Oct;56(5):558-62. doi: 10.1590/s0104-42302010000500017.
To evaluate the effects of treatment with Trifolium pratense on climacteric symptoms and sexual satisfaction in postmenopausal women.
This is a prospective, randomized, double-blind, placebo-controlled study. Initially, 120 women aged 45-65 years with menopausal symptoms, more than 12-month amenorrhea and no treatment in the past six months were selected. The participants were then divided into two groups: TG – receiving 40 mg Trifolium pratense, 1 capsule/day; PG – receiving placebo capsules containing lactose (control), 1 capsule/day. The duration of treatment was 12 months. The patients underwent clinical and laboratory evaluation before treatment and at four, eight and 12 months of treatment. The Kupperman Menopausal Index and the Golombok Rust Inventory of Sexual Satisfaction (GRISS) were used. At the end of the study, each group comprised 50 patients.
According to the Kupperman Menopausal Index, there was significant improvement in menopausal symptoms after four months of treatment, especially in relation to hot flashes, when compared to baseline data in both groups. However, no significant differences were observed between groups. There was no improvement in sexual satisfaction after treatment.
A 12-month treatment with a daily dose of 40 mg Trifolium pratense did not yield a significant improvement in menopausal symptoms and sexual satisfaction.
评估红车轴草治疗对绝经后女性更年期症状及性满意度的影响。
这是一项前瞻性、随机、双盲、安慰剂对照研究。最初，选取120名年龄在45 - 65岁、有更年期症状、闭经超过12个月且在过去六个月未接受治疗的女性。参与者随后被分为两组：治疗组（TG）——每天服用1粒含40毫克红车轴草的胶囊；安慰剂组（PG）——每天服用1粒含乳糖的安慰剂胶囊（对照）。治疗持续12个月。患者在治疗前以及治疗的第4、8和12个月接受临床和实验室评估。使用了库珀曼更年期指数和戈隆博克性满意度量表（GRISS）。研究结束时，每组有50名患者。
根据库珀曼更年期指数，与两组的基线数据相比，治疗四个月后更年期症状有显著改善，尤其是潮热方面。然而，两组之间未观察到显著差异。治疗后性满意度没有改善。
每日剂量40毫克红车轴草进行12个月的治疗，在更年期症状和性满意度方面未产生显著改善。
