Institute of Animal Husbandry and Veterinary, Fujian Academy of Agricultural Sciences, Fuzhou 350013, Fujian, People's Republic of China.
Arch Virol. 2011 Mar;156(3):405-12. doi: 10.1007/s00705-010-0866-y. Epub 2010 Dec 9.
The complete sequence of an avian paramyxovirus type 1 (APMV-1) strain, FP1/02, isolated from Muscovy duck in China, was determined. Sequence analysis indicated that the complete genome of strain FP1/02 contained 15,192 nucleotides (nt), following the rule of six. The genome contained an extra 6-nt insertion in the non-coding region of the NP gene when compared with other APMV-1 strains, such as strains La Sota and Beaudette C. The cleavage site of the F protein was (112)R-R-Q-K-R↓F(117), indicating that the FP1/02 strain was virulent, but the morbidity and mortality varied with the species of duck. Genotypic analysis based on the F gene revealed that APMV-1 FP1/02 was a member of genotype VII. Phylogenetic analysis showed that the FP1/02 strain shared high identity with other APMV-1 strains such as ZJ1, SF02 and NA-1 isolated from geese.
一株鸭源禽副黏病毒 1 型（APMV-1）分离株 FP1/02 的全基因组序列被测定。序列分析表明，与其他 APMV-1 株（如 La Sota 和 Beaudette C 株）相比，株 FP1/02 的完整基因组包含 15192 个核苷酸（nt），遵循 6 个规则。与其他 APMV-1 株相比，该株在 NP 基因的非编码区有 6-nt 的额外插入。F 蛋白的裂解位点为（112）R-R-Q-K-R↓F（117），表明 FP1/02 株是毒力株，但发病率和死亡率因鸭种而异。基于 F 基因的基因型分析表明，APMV-1 FP1/02 是基因型 VII 的成员。系统进化分析表明，FP1/02 株与其他 APMV-1 株（如鹅源 ZJ1、SF02 和 NA-1 株）具有很高的同源性。
