Teare M Dawn
Health Services Research, School of Health and Related Research, University of Sheffield, Sheffield, UK.
Methods Mol Biol. 2011;713:55-67. doi: 10.1007/978-1-60327-416-6_5.
Genetic linkage analysis concerns the estimation of genetic distance between two or more genetic loci. In genetic epidemiology, it is predominantly used to identify, or map, a genetic locus that is associated with quantitative trait variation or, in the case of binary or discrete traits, modification of the risk of being affected with a disease or phenotype. Linkage analysis uses a panel of reference genetic markers to track the segregation of genomic segments within families or sets of relatives. Individuals within the families must be measured for the trait, and often the families have been selected because they segregate the phenotype of interest.
遗传连锁分析涉及对两个或多个基因座之间遗传距离的估计。在遗传流行病学中，它主要用于识别或定位与数量性状变异相关的基因座，或者在二元或离散性状的情况下，用于定位与患某种疾病或表型风险改变相关的基因座。连锁分析使用一组参考遗传标记来追踪家族或亲属群体中基因组片段的分离情况。必须对家族中的个体进行该性状的测量，而且这些家族通常是因为分离出感兴趣的表型而被选中的。
