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γ干扰素联合乙胺嘧啶或克林霉素治疗小鼠弓形虫病的活性。

Activity of gamma interferon in combination with pyrimethamine or clindamycin in treatment of murine toxoplasmosis.

作者信息

Israelski D, Remington J

机构信息

Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, California 94301.

出版信息

Eur J Clin Microbiol Infect Dis. 1990 May;9(5):358-60. doi: 10.1007/BF01973746.

DOI:10.1007/BF01973746
PMID:2115442
Abstract

The activity of recombinant gamma interferon (rIFN-gamma) in combination with either pyrimethamine or clindamycin was examined in a murine model of acute toxoplasmosis. Mice received either pyrimethamine or clindamycin alone or in combination with rIFN-gamma. Significantly increased survival and/or time to death was observed in animals treated with pyrimethamine or clindamycin in combination with rIFN-gamma compared to those that received treatment with any of the agents alone.

摘要

在急性弓形虫病的小鼠模型中，检测了重组γ干扰素（rIFN-γ）与乙胺嘧啶或克林霉素联合使用时的活性。小鼠单独接受乙胺嘧啶或克林霉素治疗，或与rIFN-γ联合使用。与单独接受任何一种药物治疗的动物相比，接受乙胺嘧啶或克林霉素与rIFN-γ联合治疗的动物存活率显著提高和/或死亡时间显著延长。

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本文引用的文献

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Effect of clindamycin on acute and chronic toxoplasmosis in mice.克林霉素对小鼠急性和慢性弓形虫病的影响。
Antimicrob Agents Chemother. 1974 Jun;5(6):647-51. doi: 10.1128/AAC.5.6.647.
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Immunohistological study of the anatomic relationship of toxoplasma antigens to the inflammatory response in the brains of mice chronically infected with Toxoplasma gondii.对慢性感染刚地弓形虫的小鼠大脑中弓形虫抗原与炎症反应的解剖学关系进行免疫组织学研究。
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白细胞介素12与阿托伐醌或克林霉素联合治疗可显著提高急性弓形虫病小鼠的存活率。
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6
Synergistic activity of azithromycin and gamma interferon in murine toxoplasmosis.阿奇霉素与γ干扰素在小鼠弓形虫病中的协同活性
Antimicrob Agents Chemother. 1991 Aug;35(8):1672-3. doi: 10.1128/AAC.35.8.1672.
小鼠干扰素γ对小鼠弓形虫病的影响。
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Clindamycin in a murine model of toxoplasmic encephalitis.克林霉素在小鼠弓形虫性脑炎模型中的应用
Antimicrob Agents Chemother. 1987 Apr;31(4):492-6. doi: 10.1128/AAC.31.4.492.
5
Treatment of toxoplasmic encephalitis with intravenous clindamycin.静脉注射克林霉素治疗弓形虫性脑炎。
Arch Intern Med. 1988 Nov;148(11):2477-82.
6
Interferon-gamma: the major mediator of resistance against Toxoplasma gondii.干扰素-γ：抗刚地弓形虫的主要介质。
Science. 1988 Apr 22;240(4851):516-8. doi: 10.1126/science.3128869.
7
In vivo synergism of roxithromycin (RU 965) and interferon against Toxoplasma gondii.罗红霉素（RU 965）与干扰素对刚地弓形虫的体内协同作用。
Antimicrob Agents Chemother. 1987 Feb;31(2):346-8. doi: 10.1128/AAC.31.2.346.
8
In vitro and in vivo activation of human mononuclear phagocytes by interferon-gamma. Studies with normal and AIDS monocytes.
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9
[Zidovudine efficacy and tolerance in 32 patients with cerebral toxoplasmosis in the acquired immunodeficiency syndrome].齐多夫定对32例获得性免疫缺陷综合征合并脑弓形虫病患者的疗效及耐受性
Presse Med. 1988 Oct 15;17(35):1813-4.
10
Zidovudine antagonizes the action of pyrimethamine in experimental infection with Toxoplasma gondii.齐多夫定在实验性弓形虫感染中可拮抗乙胺嘧啶的作用。
Antimicrob Agents Chemother. 1989 Jan;33(1):30-4. doi: 10.1128/AAC.33.1.30.