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阿奇霉素与γ干扰素在小鼠弓形虫病中的协同活性

Synergistic activity of azithromycin and gamma interferon in murine toxoplasmosis.

作者信息

Araujo F G, Remington J S

机构信息

Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, Palo Alto, California 94301.

出版信息

Antimicrob Agents Chemother. 1991 Aug;35(8):1672-3. doi: 10.1128/AAC.35.8.1672.

DOI:10.1128/AAC.35.8.1672
PMID:1656872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC245240/
Abstract

A dose of 75 mg of azithromycin per kg of body weight per day combined with a dose of 2 micrograms of gamma interferon per day and administered for 10 days protected at least 40% of mice infected with a lethal inoculum of Toxoplasma gondii. Azithromycin administered alone protected less than 10% of the mice; gamma interferon had no protective effect.

摘要

每天每千克体重服用75毫克阿奇霉素，并结合每天2微克γ干扰素，连续给药10天，可保护至少40%感染致死剂量刚地弓形虫的小鼠。单独使用阿奇霉素仅保护不到10%的小鼠；γ干扰素没有保护作用。

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本文引用的文献

1
Effect of murine interferon gamma on murine toxoplasmosis.小鼠干扰素γ对小鼠弓形虫病的影响。
J Infect Dis. 1984 Dec;150(6):961-2. doi: 10.1093/infdis/150.6.961.
2
Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome.获得性免疫缺陷综合征患者对甲氧苄啶-磺胺甲恶唑的不良反应。
Ann Intern Med. 1984 Apr;100(4):495-9. doi: 10.7326/0003-4819-100-4-495.
3
Toxoplasmic encephalitis in patients with AIDS.艾滋病患者的弓形虫性脑炎
Infect Dis Clin North Am. 1988 Jun;2(2):429-45.
4
Azithromycin, a macrolide antibiotic with potent activity against Toxoplasma gondii.阿奇霉素，一种对弓形虫具有强效活性的大环内酯类抗生素。
Antimicrob Agents Chemother. 1988 May;32(5):755-7. doi: 10.1128/AAC.32.5.755.
5
Activity of gamma interferon in combination with pyrimethamine or clindamycin in treatment of murine toxoplasmosis.γ干扰素联合乙胺嘧啶或克林霉素治疗小鼠弓形虫病的活性。
Eur J Clin Microbiol Infect Dis. 1990 May;9(5):358-60. doi: 10.1007/BF01973746.