Hofflin J M, Remington J S
Antimicrob Agents Chemother. 1987 Feb;31(2):346-8. doi: 10.1128/AAC.31.2.346.
We investigated the activity of roxithromycin (RU 965) and gamma interferon alone and in combination in a murine model of toxoplasmic encephalitis. Roxithromycin at a dosage of 35 or 50 mg per mouse per day decreased mortality. Gamma interferon alone significantly prolonged time to death. When combined, the two agents were remarkably synergistic.
我们在小鼠弓形虫性脑炎模型中研究了罗红霉素(RU 965)和γ干扰素单独及联合使用的活性。每天每只小鼠给予35或50毫克罗红霉素可降低死亡率。单独使用γ干扰素可显著延长死亡时间。两者联合使用时具有显著的协同作用。