As'ad Al-Hamad Dermatology Center, Al-Sabah Hospital, Kuwait.
Int J Dermatol. 2010 Dec;49(12):1393-8. doi: 10.1111/j.1365-4632.2010.04567.x.
Mycosis fungoides (MF) is an indolent, most common type of cutaneous T-cell lymphoma (CTCL) with an average estimated incidence of 0.5 cases per 100,000 persons per year in the western world. Although various clinical and epidemiological features are well delineated in the western population, the data is scarce from our region.
To study the clinicoepidemiological features of MF from Kuwait.
A referral photobiology unit for cutaneous lymphomas in a national dermatology department in collaboration with three other dermatology departments in Kuwait and Kuwait cancer center.
One hundred and ninety-three cases of MF registered between July 1991 and June 2006 were included for this study.
Eighty-six percent of our MF cases were of Arab ethnicity. Males outnumbered the females by 2:1 ratio. Mean age at diagnosis was 35.20 ± 14.37 years, and 16% of the patients were diagnosed by the age 20 years. The annual incidence rate (IR) of MF in Kuwait was observed to be 0.43 cases per 100,000 persons with a significantly higher IR among Arabs as compared to non-Arab Asians (RR = 4.4; 95% CI = 2.9-6.6). A successive rise in the IR of MF was noticed with the advancing age. The annual IR among males was more or less comparable to that of females. Skin patches were the most prevalent skin lesions (67%) at diagnosis, and 22% of the patients had a pure hypopigmented variant. Patients with hypopigmented MF were observed to have younger mean age at diagnosis (27.60 ± 12.42 years) as compared to other MF cases (38.14 ± 14.37 years) (P = 0.000). Ninety-two percent of the patients had the early stage (IA, IB, and IIA) of disease.
Our patients with MF were observed to have a relatively younger age at diagnosis, with a high proportion of patients diagnosed by the age 20 years. Arabs were observed to have a higher annual IR of MF as compared to non-Arab Asians. Hypopigmented MF is prevalent in our population. The study highlights the ethnic and/or regional variations in the clinicoepidemiological characteristics of MF.
蕈样肉芽肿（MF）是一种惰性、最常见的皮肤 T 细胞淋巴瘤（CTCL），在西方世界，其年平均估计发病率为每 10 万人中有 0.5 例。尽管在西方人群中已经很好地描述了各种临床和流行病学特征，但来自我们地区的数据却很少。
研究科威特蕈样肉芽肿的临床流行病学特征。
在一个国家皮肤科部门的转诊光生物学单位，与科威特的三个其他皮肤科部门和科威特癌症中心合作。
1991 年 7 月至 2006 年 6 月期间登记的 193 例 MF 病例被纳入本研究。
我们的 MF 病例中有 86%是阿拉伯种族。男性比女性多 2:1。诊断时的平均年龄为 35.20±14.37 岁，16%的患者在 20 岁之前被诊断出。科威特 MF 的年发病率（IR）观察到为每 10 万人中有 0.43 例，阿拉伯人比非阿拉伯亚洲人明显更高（RR=4.4；95%CI=2.9-6.6）。随着年龄的增长，MF 的 IR 呈连续上升趋势。男性的年发病率与女性大致相当。皮肤斑块是最常见的皮肤病变（67%），22%的患者有单纯色素减退变异型。与其他 MF 病例相比，患有色素减退性 MF 的患者观察到诊断时的平均年龄更小（27.60±12.42 岁）（P=0.000）。92%的患者处于疾病的早期阶段（IA、IB 和 IIA）。
我们观察到 MF 患者的诊断年龄相对较小，有相当比例的患者在 20 岁之前被诊断出。与非阿拉伯亚洲人相比，阿拉伯人 MF 的年发病率更高。在我们的人群中，色素减退性 MF 较为常见。该研究强调了 MF 的临床流行病学特征在种族和/或地区方面的差异。
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