Nanda Arti, AlSaleh Qasem A, Al-Ajmi Hejab, Al-Sabah Homoud, Elkashlan Muhammad, Al-Shemmari Salem, Demierre Marie-France
As'ad Al-Hamad Dermatology Center, Al-Sabah Hospital, Kuwait.
Pediatr Dermatol. 2010 Nov-Dec;27(6):607-13. doi: 10.1111/j.1525-1470.2010.01129.x.
Mycosis fungoides (MF) is rare in children and adolescents. This study was aimed to determine the clinicoepidemiologic features of juvenile onset (≤18 yrs) MF in Kuwait. Thirty-six children and adolescents (≤18 yrs) with MF registered in a referral photobiology unit for cutaneous lymphomas between July 1991 and June 2009 were included in this study. Children and adolescents were observed to constitute 16.6% of the total number of patients with MF, with 97% of patients of Arab ethnicity. The age-adjusted incidence rate of MF in children and adolescents among the total population was 0.29/100,000 persons/year. Among 36 Arab children and adolescents, boys outnumbered girls by 1.25:1. Mean and median age at onset of disease was 9 years, and age at diagnosis was 13 years. Patch stage disease was the most common clinical variant (75%) with 56% with pure hypopigmented MF-variant. The majority of patients (75%) had stage IB (TNM and B staging) disease. The study highlights a high prevalence and incidence of juvenile MF in Kuwait with a predominantly hypopigmented presentation.
蕈样肉芽肿（MF）在儿童和青少年中较为罕见。本研究旨在确定科威特青少年期（≤18岁）MF的临床流行病学特征。本研究纳入了1991年7月至2009年6月间在一家转诊的皮肤淋巴瘤光生物学单位登记的36例儿童和青少年（≤18岁）MF患者。观察发现儿童和青少年占MF患者总数的16.6%，其中97%为阿拉伯族裔。儿童和青少年中MF在总人口中的年龄调整发病率为0.29/10万人口/年。在36例阿拉伯儿童和青少年中，男孩与女孩的比例为1.25:1。疾病发病的平均年龄和中位年龄为9岁，诊断时的年龄为13岁。斑片期疾病是最常见的临床类型（75%），其中56%为单纯色素减退型MF变异型。大多数患者（75%）为IB期（TNM和B分期）疾病。该研究强调科威特青少年MF的高患病率和发病率，且主要表现为色素减退。
