Fatemi Naeini Farahnaz, Sadeghiyan Hamidreza, Pourazizi Mohsen, Najafian Jamshid, Abtahi-Naeini Bahareh
Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
Int Sch Res Notices. 2014 Dec 24;2014:820921. doi: 10.1155/2014/820921. eCollection 2014.
Background. Primary cutaneous T-cell lymphomas (CTCLs) are a group of extranodal non-Hodgkin lymphomas that may be present in the skin without any evidence of extracutaneous disease. The aim of this study was to evaluate the epidemiological characteristics of primary CTCL in Isfahan, Iran. Method. A total of 95 patients who were diagnosed as having primary CTCL were recruited during a 10-year period (2003-2013) and were classified according to the new WHO-EORTC criteria. Results. The patient group consisted of 43 (44.8%) males and 53 (55.2%) females, which indicated a female predominance (M : F ratio 1 : 1.2). The mean age at the time of diagnosis was 41.78 ± 16.88 years (range: 7-84 years). Prior to diagnosis, the lesions had persisted for a mean of 8.34 ± 4.38 years (range: 0-55 years). The age at peak diagnosis was 20-40 years (43%). The most frequent subtypes were mycosis fungoides (MF) (88.5%). Four patients died from CTCL-related complications. Conclusions. The distinguishing epidemiologic characteristics of primary CTCL, particularly those MF, in Iran, are the absence of a male predominance and lower age at diagnosis. This is likely because of the characteristic ethnic group diversity and increased susceptibility among younger population.
背景。原发性皮肤T细胞淋巴瘤（CTCL）是一组结外非霍奇金淋巴瘤，可出现在皮肤，而无任何皮肤外疾病的证据。本研究旨在评估伊朗伊斯法罕原发性CTCL的流行病学特征。方法。在10年期间（2003 - 2013年）共招募了95例被诊断为原发性CTCL的患者，并根据世界卫生组织-欧洲肿瘤研究与治疗组织（WHO-EORTC）的新标准进行分类。结果。患者组包括43名男性（44.8%）和53名女性（55.2%），显示女性占优势（男∶女比例为1∶1.2）。诊断时的平均年龄为41.78±16.88岁（范围：7 - 84岁）。诊断前，皮损平均持续8.34±4.38年（范围：0 - 55年）。诊断高峰年龄为20 - 40岁（43%）。最常见的亚型是蕈样肉芽肿（MF）（88.5%）。4例患者死于CTCL相关并发症。结论。伊朗原发性CTCL，尤其是MF的独特流行病学特征是不存在男性优势且诊断年龄较低。这可能是由于独特的种族群体多样性以及年轻人群易感性增加所致。
