O'Brien Taylor Q, Clark-Price Stuart C, Evans Erika E, Di Fazio Renata, McMichael Maureen A
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA.
J Am Vet Med Assoc. 2010 Dec 15;237(12):1455-8. doi: 10.2460/javma.237.12.1455.
A 5-year-old castrated male domestic shorthair cat was examined because of presumptive lidocaine intoxication. Thirty minutes earlier, the cat had received an SC injection of approximately 140 mg of lidocaine hydrochloride (20 mg/kg [9.1 mg/lb]) to facilitate closure of a wound on the left pelvic limb.
Initial physical examination revealed severe lethargy and respiratory distress; erratic, poor-quality pulses with severe hypotension; and pulmonary edema.
Initial supportive treatment included administration of oxygen and IV administration of lactated Ringer's solution. Additional treatment with a 20% lipid emulsion (1.5 mL/kg [0.68 mL/lb], IV) delivered over a 30-minute period resulted in dramatic improvement in cardiovascular and behavioral variables. No adverse effects from lipid emulsion were detected on routine hematologic evaluation, thoracic radiography, or computed tomography.
IV administration of a lipid emulsion was used in the treatment of lidocaine intoxication in a cat. Rapid infusion of a lipid emulsion may be a therapeutic option for veterinary patients with toxicosis attributable to local anesthetics or other lipid-soluble drugs.
一只5岁去势的雄性家猫因疑似利多卡因中毒接受检查。30分钟前，这只猫接受了皮下注射约140毫克盐酸利多卡因（20毫克/千克[9.1毫克/磅]），以促进左后肢伤口的闭合。
初次体格检查发现严重嗜睡和呼吸窘迫；脉搏不规则、质量差且伴有严重低血压；还有肺水肿。
初始支持治疗包括给氧和静脉输注乳酸林格氏液。在30分钟内静脉输注20%脂质乳剂（1.5毫升/千克[0.68毫升/磅]）进行额外治疗后，心血管和行为变量有显著改善。在常规血液学评估、胸部X光或计算机断层扫描中未检测到脂质乳剂的不良反应。
静脉输注脂质乳剂用于治疗猫的利多卡因中毒。快速输注脂质乳剂可能是治疗因局部麻醉药或其他脂溶性药物中毒的兽医患者的一种治疗选择。
