Public Health, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Hum Reprod. 2011 Feb;26(2):466-72. doi: 10.1093/humrep/deq343. Epub 2010 Dec 14.
No epidemiological studies have examined risk factors for early spontaneous abortions among Japanese women. In this matched case-control study, we investigated the associations of reproductive, physical, and lifestyle characteristics of women and their husbands with early spontaneous abortion <12 weeks of gestation.
Information was collected through medical records for 430 cases of early spontaneous abortion and 860 controls of term delivery. Two controls were individual-matched to one case according to maternal age (± 3 years) and calendar year of events (either early spontaneous abortion or delivery). Multivariable conditional odds ratios (ORs) and 95% confidence interval (CI) were calculated with conditional logistic-regression.
The risk of early spontaneous abortions was higher for women with a past history of early spontaneous abortions; OR was 1.98 (95% CI: 1.35, 2.89) for one previous spontaneous abortion, 2.36 (95% CI: 1.47, 3.79) for two, and 8.73 (95% CI: 5.22, 14.62) for three or more. Other factors also influence risk; an OR of 2.39 (95% CI: 1.26, 4.25) was found for women who smoked, and 1.65 (95%CI: 1.17, 2.35) for women working outside the home.
Our finding suggests that for Japanese women, smoking and working may be important public health issue targets for the prevention of early spontaneous abortions.
目前尚无研究调查日本女性早期自然流产的危险因素。在这项匹配的病例对照研究中，我们调查了女性及其丈夫的生殖、身体和生活方式特征与 12 周内早期自然流产的关系。
通过病历收集了 430 例早期自然流产病例和 860 例足月分娩对照的信息。根据产妇年龄（± 3 岁）和事件发生的日历年份（早期自然流产或分娩），将 2 名对照与 1 名病例进行个体匹配。采用条件逻辑回归计算多变量条件比值比（OR）和 95%置信区间（CI）。
有早期自然流产史的女性发生早期自然流产的风险更高；一次自然流产的 OR 为 1.98（95%CI：1.35，2.89），两次为 2.36（95%CI：1.47，3.79），三次或更多为 8.73（95%CI：5.22，14.62）。其他因素也影响风险；吸烟女性的 OR 为 2.39（95%CI：1.26，4.25），外出工作的女性为 1.65（95%CI：1.17，2.35）。
我们的研究结果表明，对于日本女性来说，吸烟和外出工作可能是预防早期自然流产的重要公共卫生问题目标。
