School of Psychology, University of Adelaide, SA, Australia.
J Geriatr Psychiatry Neurol. 2011 Mar;24(1):33-8. doi: 10.1177/0891988710390813. Epub 2010 Dec 14.
While rates of mild cognitive impairment (MCI) are relatively high in populations with cardiovascular diseases and risk factors, screening tests for MCI have not been evaluated in this patient group. This study investigated the sensitivity and specificity of the Montreal Cognitive Assessment (MoCA) tool for detecting MCI in 110 patients (mean age 67.9 + 11.7 years; 60% female) recruited from hospital cardiovascular outpatient clinics. Mean MoCA performance was relatively low (22.8 + 3.8) in this group, with 72.1% of participants scoring below the recommended cutoff for cognitive impairment (<26). The presence of MCI was determined using the Neuropsychological Assessment Battery Screening Module (NAB-SM). Both amnestic MCI and multiple-domain MCI were identified. The optimum MoCA cutoff for detecting MCI in this group was <24. At this cutoff, the MoCA's sensitivity for detecting amnestic MCI was 100% and for multiple-domain MCI it was 83.3%. Specificity rates for amnestic MCI and multiple-domain MCI were 50.0% and 52% respectively. The poor specificity of the MoCA suggests that it will have limited value as a screening test for MCI in settings where the overall prevalence of MCI is low.
虽然在患有心血管疾病和相关风险因素的人群中，轻度认知障碍（MCI）的发病率相对较高，但针对该患者群体的 MCI 筛查测试尚未得到评估。本研究旨在调查蒙特利尔认知评估（MoCA）工具在 110 名（平均年龄 67.9±11.7 岁；60%为女性）从医院心血管门诊招募的患者中检测 MCI 的敏感性和特异性。该组患者的 MoCA 平均表现相对较低（22.8±3.8），72.1%的参与者的得分低于认知障碍的推荐临界值（<26）。MCI 的存在是使用神经心理评估电池筛查模块（NAB-SM）确定的。发现了遗忘型 MCI 和多领域 MCI。该组中，MoCA 检测 MCI 的最佳截断值为<24。在此截断值下，MoCA 检测遗忘型 MCI 的敏感性为 100%，检测多领域 MCI 的敏感性为 83.3%。遗忘型 MCI 和多领域 MCI 的特异性率分别为 50.0%和 52%。MoCA 的特异性较差表明，在 MCI 的总体患病率较低的情况下，它作为 MCI 的筛查测试的价值有限。
