Rupesh S, Winnier J J, Nayak U A, Rao A P, Reddy N V
Department of Pedodontics and Preventive Dentistry, Pushpagiri College of Dental Sciences, Perumthuruthy, Kerala, India.
J Indian Soc Pedod Prev Dent. 2010 Jul-Sep;28(3):138-44. doi: 10.4103/0970-4388.73780.
The literature is replete with studies establishing Streptococcus mutans as a major player in the formation of pit and fissure caries in all dentitions. Salivary bacterial levels in turn are related to the number of colonized surfaces. Therefore, decreasing the salivary levels of S. mutans would have a great benefit in decreasing the incidence of dental diseases.
Keeping in mind the potential antimicrobial effects of saturated saline and alum solutions, the present study was attempted to compare and evaluate the effects of saturated saline rinse and 0.02 M alum mouthrinse on salivary S. mutans levels in children.
The investigation was a double-blind, stratified comparison of three parallel groups of children who used either saturated saline rinse, 0.02 M alum mouthrinse or distilled water (placebo) rinse twice daily under professional supervision for a 21-day period. A total of three saliva samples were taken from each individual - at baseline, on the 10 th day and on the 21 st day, and colony counts of S. mutans were determined. All data were subjected to statistical analysis using Wilcoxon's Signed Ranks Sum and Mann-Whitney "U" test.
Children using saturated saline rinse and alum rinse showed statistically significant reductions in salivary S. mutans counts after 10 days and also after 21 days. After 21 days, the saturated saline rinse and alum rinse groups showed statistically significant differences over the placebo rinse group. Again, the alum rinse group showed a statistically significant difference over the saturated saline rinse group.
文献中充斥着大量研究，证实变形链球菌是所有牙列中窝沟龋形成的主要因素。唾液细菌水平又与被定植表面的数量相关。因此，降低唾液中变形链球菌的水平对降低牙科疾病的发病率将有很大益处。
鉴于饱和盐水和明矾溶液的潜在抗菌作用，本研究试图比较和评估饱和盐水漱口和0.02M明矾漱口水对儿童唾液中变形链球菌水平的影响。
本调查是一项双盲、分层比较研究，将三组平行的儿童分为三组，分别在专业监督下每天使用饱和盐水漱口、0.02M明矾漱口水或蒸馏水（安慰剂）漱口两次，为期21天。从每个个体采集总共三份唾液样本——在基线、第10天和第21天，并测定变形链球菌的菌落计数。所有数据均使用Wilcoxon符号秩和检验和Mann-Whitney “U”检验进行统计分析。
使用饱和盐水漱口和明矾漱口的儿童在10天后以及21天后唾液中变形链球菌计数均有统计学意义的降低。21天后，饱和盐水漱口组和明矾漱口组与安慰剂漱口组相比有统计学意义的差异。此外，明矾漱口组与饱和盐水漱口组相比有统计学意义的差异。
