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0.2%氯己定与草本漱口水对唾液抗菌效果的比较:一项随机对照试验性研究

Comparison of Antimicrobial Efficacy of (between) 0.2% Chlorhexidine and Herbal Mouthwash on Salivary : A Randomized Controlled Pilot Study.

作者信息

Shah Swara, Bargale Seema, Dave Bhavna H, Deshpande Anshula, Kariya Pratik B, Karri Anuradha

机构信息

Department of Paedodontics and Preventive Dentistry, K M Shah Dental College, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.

出版信息

Contemp Clin Dent. 2018 Jul-Sep;9(3):440-445. doi: 10.4103/ccd.ccd_264_18.

Abstract

BACKGROUND

The chemomechanical plaque control measures are helpful in controlling dental plaque and thus caries, especially in pediatric age group.

AIM

This study aims to compare effectiveness of herbal mouthrinse containing to that of 0.2% chlorhexidine against children's salivary mutans streptococci levels.

SETTINGS AND DESIGN

A double-blind, randomized, controlled study design will be framed for conducting this study.

METHODS

A total of 45 participants were randomly categorized in Group 1, Group 2, or Group 3 (control group, experimental group, or negative control). Baseline unstimulated saliva was collected. All the participants were instructed regarding the use of mouthrinse for 2 weeks. After 2 weeks, again unstimulated saliva was collected. After collection, saliva samples were sent for microbiological analysis.

STATISTICAL ANALYSIS

The mean colony-forming units (CFU/ml) were determined. Paired -test, ANOVA test, and test were applied for statistical analysis.

RESULTS

Statistically significant difference in CFU count has been observed in 0.2% chlorhexidine and Oratreat groups at 15 days as compared to baseline ( < 0.001). At 15 days, reduction in CFU count has seen more in Oratreat group as compared to 0.2% chlorhexidine group, and the difference is statistically significant ( < 0.001).

CONCLUSION

0.2% chlorhexidine and Oratreat mouthwash reduce the salivary count. Oratreat herbal mouthwash has proved to be better as compared to 0.2% chlorhexidine mouthwash.

摘要

背景

化学机械菌斑控制措施有助于控制牙菌斑,进而预防龋齿,在儿童年龄组中尤为如此。

目的

本研究旨在比较含[具体成分]的草本漱口水与0.2%氯己定对儿童唾液变形链球菌水平的有效性。

设置与设计

将采用双盲、随机、对照研究设计来开展本研究。

方法

总共45名参与者被随机分为第1组、第2组或第3组(对照组、实验组或阴性对照组)。收集基线非刺激性唾液。指导所有参与者使用漱口水2周。2周后,再次收集非刺激性唾液。收集后,将唾液样本送去进行微生物分析。

统计分析

确定平均菌落形成单位(CFU/ml)。应用配对t检验、方差分析和[具体检验方法]进行统计分析。

结果

与基线相比,在第15天时,0.2%氯己定组和奥拉治疗组的CFU计数有统计学显著差异(P<0.001)。在第15天时,奥拉治疗组的CFU计数下降幅度比0.2%氯己定组更大,且差异具有统计学意义(P<0.001)。

结论

0.2%氯己定和奥拉治疗漱口水可降低唾液[具体细菌]计数。事实证明,奥拉治疗草本漱口水比0.2%氯己定漱口水效果更好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4645/6104363/c19c8e094bbb/CCD-9-440-g001.jpg

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