Uehara Nobuo
Department of Applied Chemistry, Graduate School of Engineering, Utsunomiya University, Tochigi, Japan.
Anal Sci. 2010;26(12):1219-28. doi: 10.2116/analsci.26.1219.
In this brief review, gold nanoparticles conjugated with functional polymers are described from the viewpoint of application to sensing materials. The optical properties of gold nanoparticles, the synthesis of polymer-functionalized gold nanoparticles, and their analytical applications are discussed. Polymer-functionalized gold nanoparticles are categorized into two classes: biopolymer-conjugated gold nanoparticles and artificial-polymer conjugated gold nanoparticles. Fluorometric and colorimetric sensing using gold nanoparticles are focused; fluorometric detection enables us to exploit sensitive assays for practical use. Furthermore, chemical amplification using gold nanoparticles is also discussed for the sensitive probing.
在这篇简短的综述中，从传感材料应用的角度描述了与功能聚合物共轭的金纳米颗粒。讨论了金纳米颗粒的光学性质、聚合物功能化金纳米颗粒的合成及其分析应用。聚合物功能化金纳米颗粒可分为两类：生物聚合物共轭金纳米颗粒和人工聚合物共轭金纳米颗粒。重点介绍了使用金纳米颗粒的荧光和比色传感；荧光检测使我们能够开发出实际应用的灵敏检测方法。此外，还讨论了使用金纳米颗粒进行化学放大以实现灵敏探测。
