针对皮肤炎症中的白细胞介素-1家族成员。
Targeting the IL-1 family members in skin inflammation.
作者信息
Jensen Liselotte E
机构信息
Temple University School of Medicine, Department of Microbiology and Immunology, 1158 MERB, 3500 North Broad Street, Philadelphia, PA 19140-4106, USA.
出版信息
Curr Opin Investig Drugs. 2010 Nov;11(11):1211-20.
Abstract
The IL-1 family of cytokines comprises 11 proteins with pro- and anti-inflammatory functions that are mediated through an equally large group of receptors and coreceptors. Dysregulation of the IL-1 system may lead to diseases such as psoriasis, atopic dermatitis, contact dermatitis and cutaneous lupus erythematosus. These inflammatory skin conditions greatly affect quality of life and life expectancy, and their frequencies are increasing. However, treatment options for these diseases are unsatisfactory. This review briefly summarizes new findings, reported in the past 2 years, implicating IL-1 family members in skin inflammation. Furthermore, how the biological activities of the IL-1 family members may be inhibited is discussed.
摘要
白细胞介素-1（IL-1）细胞因子家族由11种具有促炎和抗炎功能的蛋白质组成，这些功能通过同样庞大的一组受体和共受体介导。IL-1系统的失调可能导致诸如银屑病、特应性皮炎、接触性皮炎和皮肤红斑狼疮等疾病。这些炎症性皮肤病极大地影响生活质量和预期寿命，且其发病率正在上升。然而，这些疾病的治疗选择并不令人满意。本综述简要总结了过去两年报道的有关IL-1家族成员与皮肤炎症相关的新发现。此外，还讨论了如何抑制IL-1家族成员的生物学活性。
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