Andrysek O, Horák J, Vítek P
Oddĕleni klinicke onkologie, Na slupi, Praha.
Bratisl Lek Listy. 1990 Apr;91(4):289-91.
Intraarterial chemotherapy was used to affect inoperable or relapsing tumors of the rectum or rectosigmoid. Seldinger's approach was used to catheterize both internal iliac arteries and recently also the inferior mesenteric artery in the second stage. Of the cytostatics mitomycin C 2 x 10 mg/2 h and fluorouracil 2 x 500 mg/24 h were administered over four days. No skin damage was observed in the region supplied by the branches of the catheterized arteries as simultaneously hydrocortisone was administered intraarterially in doses of 2 x 50 mg/24 h in the first two days and 2 x 25 mg/24 h in the remaining two days. No adverse effects of the treatment were recorded. Of the nine patients over 50% regression was achieved in 3 cases established by CT, stabilization of the process in 2 cases, and in 4 cases objectivization failed. Remission of symptoms and improvement of performance was observed in 8 patients, in 1 patient the method failed to be effective. Intraarterial chemotherapy of the pelvic region is considered suitable also for preoperative cytoreduction.
动脉内化疗用于治疗无法手术切除或复发的直肠或直肠乙状结肠肿瘤。采用Seldinger技术在第一阶段对双侧髂内动脉进行插管，近期在第二阶段也对肠系膜下动脉进行插管。在四天内给予细胞抑制剂丝裂霉素C 2×10mg/2小时和氟尿嘧啶2×500mg/24小时。在插管动脉分支供血区域未观察到皮肤损伤，因为在前两天同时动脉内给予氢化可的松，剂量为2×50mg/24小时，在其余两天为2×25mg/24小时。未记录到治疗的不良反应。在9例患者中，通过CT确定3例实现了超过50%的肿瘤退缩，2例病情稳定，4例客观缓解失败。8例患者症状缓解且身体状况改善，1例患者该方法无效。盆腔区域的动脉内化疗也被认为适用于术前肿瘤细胞减灭。
