Medical Microbiology Department, Faculty of Medicine, Gazi University, Ankara, Turkey.
Curr Eye Res. 2011 Mar;36(3):179-89. doi: 10.3109/02713683.2010.533810. Epub 2010 Dec 15.
Microbiology, clinical perspective of ocular fungal infections, and the experimental models were overviewed.
Review of published studies were evaluated and personal experience was mentioned. In this review, clinical features of keratitis and endogenous and exogenous endophthalmitis are also mentioned, but this article mainly focused on laboratory diagnosis and the experimental models of ophthalmic mycoses.
Fungal infections were discussed according to the anatomical part of the eye involved in the disease. Trauma is the most important predisposing cause; the species of Fusarium, Aspergillus, and Candida are the most frequently isolated organisms. Laboratory methods, such as culture, remains the cornerstone of diagnosis; direct microscopic detection of fungal structures in ocular samples permits a rapid presumptive diagnosis. New approaches, such as serological and molecular methods, have been widely used in recent years. A variety of antifungals have been evaluated in the therapy of this condition. Experimental models would facilitate investigations exploring the pathophysiology, cell biology, genetics, immunology, and therapy of this disease.
Fungal infections of the eye continue to be an important cause of ocular morbidity, particularly in the developing world. Understanding ocular infections will improve the outcome of this condition.
综述了眼部真菌感染的微生物学、临床视角和实验模型。
评估了已发表研究的综述，并提到了个人经验。在这篇综述中，还提到了角膜炎和眼内源性和外源性眼内炎的临床特征，但本文主要侧重于眼科真菌感染的实验室诊断和实验模型。
根据疾病涉及的眼部解剖部位讨论了真菌感染。创伤是最重要的诱发因素；最常分离到的生物体是镰刀菌属、曲霉菌属和假丝酵母菌属。培养等实验室方法仍然是诊断的基石；眼部样本中真菌结构的直接显微镜检测可快速进行初步诊断。近年来，血清学和分子方法等新方法已被广泛应用。已经评估了多种抗真菌药物治疗这种情况。实验模型将有助于探索这种疾病的病理生理学、细胞生物学、遗传学、免疫学和治疗方法的研究。
眼部真菌感染仍然是眼部发病率的重要原因，特别是在发展中国家。了解眼部感染将改善这种疾病的预后。
