Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, The University of Toronto, and Dental Clinic, Princess Margaret Hospital, 124 Edward Street, Office 350A, Toronto, M5G 1G6, Ontario, Canada.
Dentomaxillofac Radiol. 2011 Jan;40(1):60-4. doi: 10.1259/dmfr/85668294.
Central giant cell granuloma (CGCG) is a benign intraosseous lesion. The true nature of this lesion is controversial and remains unknown; the three competing theories are that it could be a reactive lesion, a developmental anomaly or a benign neoplasm. Furthermore, the actual aetiology of CGCG is still unclear, although inflammation, haemorrhage and local trauma have all been suggested; it has also been hypothesized that CGCG may have a genetic aetiology. Lesions central to the mandibular condylar head are very rare, with only three documented cases in the English language literature, none of which elaborates on the CT features. In this case report, a 31-year-old male patient complaining of a left pre-auricular mass underwent radiographic investigation. CT images revealed a lesion central to the mandibular condyle and demonstrated features that were highly suggestive of CGCG. The patient underwent surgical curettage, and the subsequent histopathological examination confirmed the diagnosis of CGCG. 3 years after the procedure the patient presented with a recurrence and underwent complete resection of the mandibular condyle with immediate reconstruction. This report presents CT characteristics of a rare occurrence of CGCG of the mandibular condyle, compares it with other published cases and poses the question of the role of radiology in predicting the degree of aggressive behaviour of these lesions before surgery.
中央性 giant 细胞肉芽肿（CGCG）是一种良性骨内病变。该病变的确切性质存在争议，目前仍不清楚；三种有竞争力的理论认为它可能是一种反应性病变、发育异常或良性肿瘤。此外，CGCG 的实际病因仍不清楚，尽管炎症、出血和局部创伤都被认为是其病因；也有人假设 CGCG 可能具有遗传病因。下颌髁突头部的病变非常罕见，英文文献中仅记载了 3 例，均未详细描述 CT 特征。在本病例报告中，一名 31 岁男性患者因左耳前肿块就诊，进行了影像学检查。CT 图像显示下颌髁突中央有一病变，高度提示 CGCG。患者接受了手术刮除术，随后的组织病理学检查证实了 CGCG 的诊断。术后 3 年，患者复发，并接受了下颌髁突的完全切除和即刻重建。本报告介绍了下颌髁突 CGCG 这一罕见病例的 CT 特征，与其他已发表的病例进行了比较，并提出了影像学在预测这些病变术前侵袭性行为程度方面的作用。
