Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
J Otolaryngol Head Neck Surg. 2019 Jul 18;48(1):32. doi: 10.1186/s40463-019-0356-5.
Central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. Divided into non- and aggressive subtypes, the aggressive subtype is relatively rare and can occasionally progress rapidly, resulting in significant morbidity.
We present a case of an aggressive central giant cell granuloma (CGCG) in a six year-old female. The lesion originated in the right mandibular ramus and progressed rapidly to involve the condyle. Diagnosis was made using a combination of imaging and pathology. A timely en bloc resection of the hemi-mandible was performed with placement of a reconstructive titanium plate and condylar prosthesis.
Our case demonstrates the importance of considering CGCG in the differential diagnosis of rapidly progressive mandibular lesions in the pediatric population. Prompt diagnosis and management can greatly improve long-term outcomes.
中央性骨巨细胞瘤是下颌骨的良性肿瘤，好发于儿童和青年。分为非侵袭性和侵袭性亚型，侵袭性亚型相对少见，但偶尔会快速进展，导致严重的发病率。
我们报告了一例 6 岁女性侵袭性中央性骨巨细胞瘤（CGCG）。病变起源于右侧下颌支，迅速进展累及髁突。通过影像学和病理学相结合进行诊断。及时行半下颌骨整块切除术，同时放置重建钛板和髁突假体。
我们的病例表明，在儿童下颌骨快速进展性病变的鉴别诊断中，应考虑 CGCG。及时诊断和治疗可以大大改善长期预后。
