一家三姐妹下颌角双侧中央性巨型细胞肉芽肿。

Dental School, Vita-Salute San Raffaele University, via Olgettina 58, Milan, Italy.

School of Pediatric Dentistry, Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Lorenzo Natali 1: Località Coppito, 67100, L'Aquila, Italy.

Head Face Med. 2018 Sep 4;14(1):14. doi: 10.1186/s13005-018-0171-7.

In literature there are few reports about multiple CGCG. But this is the first report of bilateral CGCG of the mandibular angles in three females from the same family.This report describes three cases of females from the same family - a mother and two young daughters - with bilateral CGCG in their jaw angles. All the lesions were surgically removed and the histopathologic diagnosis was always identical: giant cell central granulomas, with patterns that were absolutely superimposable between them and with that of the mother.The hypothesis is that this presentation of CGCG may be defined as hereditary bilateral CGCG of the mandibular angles (or also, cherubism-like lesions).

文献中鲜有关于多发中央性颌骨骨巨细胞瘤（CGCG）的报道。但这是首例三例同一家族女性双侧下颌角 CGCG 的报告。本报告描述了来自同一家庭的三位女性——一位母亲和两位年轻的女儿——她们的下颌角均患有双侧 CGCG。所有病变均经手术切除，组织病理学诊断始终相同：均为巨细胞中央性颌骨肉芽肿，病变模式在三者之间完全一致，且与母亲的病变模式一致。我们推测，这种 CGCG 的表现可以定义为遗传性双侧下颌角 CGCG（或也可称为类 cherubism 病变）。