重复性经眶交流电刺激治疗视神经病变。
Repetitive transorbital alternating current stimulation in optic neuropathy.
机构信息
Otto-von-Guericke University of Magdeburg, Medical Faculty, Institute of Medical Psychology, Magdeburg, Germany.
出版信息
NeuroRehabilitation. 2010;27(4):335-41. doi: 10.3233/NRE-2010-0617.
BACKGROUND
Visual field defects after optic nerve damage typically show a limited capacity for spontaneous and treatment-induced recovery.
OBJECTIVE
Repetitive transorbital alternating current stimulation (rtACS) was applied to the damaged optic nerve to evaluate visual functions after stimulation.
METHODS
A 27-years-old male patient suffering left optic nerve atrophy with nearly complete loss of vision 11 years after atypical traumatic damage was treated transorbitally with biphasic 10-15 pulse trains of rtACS (10-30 Hz, < 600 μA, 30-40 min daily for 10 days) which produced phosphenes.
RESULTS
After rtACS treatment detection ability of super-threshold stimuli increased from 3.44% to 17.75% and mean perimetric threshold from 0 dB to 2.21 dB at final diagnostics.
CONCLUSION
This improvement of vision may be due to increased neuronal synchronization, possibly involving strengthening of synaptic transmission along the central visual pathway.
背景
视神经损伤后的视野缺损通常表现出自发和治疗诱导恢复的能力有限。
目的
重复经颅交流电刺激（rtACS）应用于受损视神经，以评估刺激后的视觉功能。
方法
一名 27 岁男性患者，11 年前因非典型外伤性损伤导致左眼视神经萎缩，视力几乎完全丧失，经眶内给予双相 10-15 脉冲串 rtACS（10-30 Hz，<600 μA，每日 30-40 分钟，共 10 天）治疗，产生光幻视。
结果
在 rtACS 治疗后，超阈值刺激的检测能力从 3.44%增加到 17.75%，平均视野阈值从 0dB 增加到 2.21dB。
结论
这种视力的改善可能是由于神经元同步性增加，可能涉及到中枢视觉通路中突触传递的增强。
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