Jung Park, Department of Internal Medicine, Kaiser Permanente Los Angeles Medical Center, 1526 Edgemont Ave, Los Angeles, CA 90027, United States.
World J Gastrointest Oncol. 2010 Apr 15;2(4):169-76. doi: 10.4251/wjgo.v2.i4.169.
Curcumin has been used in traditional Indian medicine for many centuries for its anti-inflammatory and anti-carcinogenic properties. There has been some promising research concerning curcumin as a safe therapeutic agent for many cancers, colorectal cancer being among them. This has been shown through research in cell cultures, animal models, and humans. At this time, it appears that curcumin's anti-carcinogenic properties are most likely due to its effects on multiple molecular targets, such as nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) and activator protein 1 (AP-1). NF-κB and AP-1 are both major transcription factors that regulate inflammation and thus affect cell proliferation, differentiation and even apoptosis. Curcumin has also been shown to affect a variety of other key players involved in carcinogenesis, such as cyclooxygenase-2, matrix metallopeptidases 2 and 9 and tumor necrosis factor α induced vascular cell adhesion molecule, just to name a few. Although many molecular targets are involved, curcumin has been well tolerated in many studies: doses up to 8 g a day have been confirmed to be safe for humans. In this brief review, we will examine the current studies and literature and touch upon many molecular pathways affected by curcumin, and demonstrate the exciting possibility of curcumin as a chemopreventive agent for colorectal cancer.
姜黄素在传统的印度医学中已经使用了几个世纪，因其具有抗炎和抗癌特性。关于姜黄素作为许多癌症的安全治疗剂，包括结直肠癌，有一些有前途的研究。这已经通过细胞培养、动物模型和人类研究得到了证实。目前，姜黄素的抗癌特性似乎最有可能是由于其对多种分子靶点的影响，如核因子 κ-轻链增强子的激活 B 细胞（NF-κB）和激活蛋白 1（AP-1）。NF-κB 和 AP-1 都是主要的转录因子，可调节炎症，从而影响细胞增殖、分化甚至凋亡。姜黄素还被证明可影响涉及致癌作用的多种其他关键因子，如环氧化酶-2、基质金属蛋白酶 2 和 9 以及肿瘤坏死因子-α诱导的血管细胞黏附分子，仅举几例。尽管涉及许多分子靶点，但在许多研究中，姜黄素已被很好地耐受：高达 8 克/天的剂量已被证实对人类是安全的。在这篇简短的综述中，我们将检查当前的研究和文献，并探讨姜黄素影响的许多分子途径，并展示姜黄素作为结直肠癌化学预防剂的令人兴奋的可能性。
