Cruz-Correa Marcia, Shoskes Daniel A, Sanchez Patricia, Zhao Rhongua, Hylind Linda M, Wexner Steven D, Giardiello Francis M
Department of Medicine, Cleveland Clinic, Weston, Florida, USA.
Clin Gastroenterol Hepatol. 2006 Aug;4(8):1035-8. doi: 10.1016/j.cgh.2006.03.020. Epub 2006 Jun 6.
BACKGROUND & AIMS: Familialadenomatous polyposis (FAP) is an autosomal-dominant disorder characterized by the development of hundreds of colorectal adenomas and eventual colorectal cancer. Regression of adenomas in this syndrome occurs with the administration of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors, but these compounds can have considerable side effects. We evaluated the efficacy of the combination of diet-derived nonprescription supplements curcumin and quercetin to regress adenomas in patients with FAP.
Five FAP patients with prior colectomy (4 with retained rectum and 1 with an ileal anal pouch) received curcumin 480 mg and quercetin 20 mg orally 3 times a day. The number and size of polyps were assessed at baseline and after therapy. The Wilcoxon signed-rank test was used to determine differences in the number and size of polyps. Treatment side effects and medication compliance also were evaluated.
All 5 patients had a decreased polyp number and size from baseline after a mean of 6 months of treatment with curcumin and quercetin. The mean percent decrease in the number and size of polyps from baseline was 60.4% (P < .05) and 50.9% (P < .05), respectively. Minimal adverse side effects and no laboratory abnormalities were noted.
The combination of curcumin and quercetin appears to reduce the number and size of ileal and rectal adenomas in patients with FAP without appreciable toxicity. Randomized controlled trials are needed to validate these findings.
家族性腺瘤性息肉病（FAP）是一种常染色体显性疾病，其特征是会出现数百个结肠直肠腺瘤并最终发展为结肠直肠癌。在该综合征中，使用非甾体抗炎药和环氧合酶 - 2抑制剂可使腺瘤消退，但这些化合物可能有相当多的副作用。我们评估了饮食来源的非处方补充剂姜黄素和槲皮素联合使用使FAP患者腺瘤消退的疗效。
5例曾行结肠切除术的FAP患者（4例保留直肠，1例有回肠肛管袋）每天口服3次480毫克姜黄素和20毫克槲皮素。在基线期和治疗后评估息肉的数量和大小。采用Wilcoxon符号秩检验来确定息肉数量和大小的差异。还评估了治疗副作用和药物依从性。
5例患者在接受姜黄素和槲皮素平均6个月的治疗后，息肉数量和大小均较基线期减少。息肉数量和大小较基线期的平均减少百分比分别为60.4%（P < 0.05）和50.9%（P < 0.05）。未观察到明显的不良副作用，也未发现实验室异常。
姜黄素和槲皮素联合使用似乎可减少FAP患者回肠和直肠腺瘤的数量和大小，且无明显毒性。需要进行随机对照试验来验证这些发现。
