内镜下黏膜下剥离术治疗浅表性食管鳞状细胞肿瘤的短期结果
Short term results of endoscopic submucosal dissection in superficial esophageal squamous cell neoplasms.
作者信息
Nonaka Kouichi, Arai Shin, Ishikawa Keiko, Nakao Masamitsu, Nakai Yousuke, Togawa Osamu, Nagata Koji, Shimizu Michio, Sasaki Yutaka, Kita Hiroto
机构信息
Kouichi Nonaka, Shin Arai, Keiko Ishikawa, Masamitsu Nakao, Yousuke Nakai, Osamu Togawa, Hiroto Kita, Department of Gastroenterology, Saitama Medical University International Medical Center, Saitama 350-1298, Japan.
出版信息
World J Gastrointest Endosc. 2010 Feb 16;2(2):69-74. doi: 10.4253/wjge.v2.i2.69.
Abstract
AIM
To evaluate the efficacy of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms.
METHODS
Between July 2007 and March 2009, 27 consecutive superficial esophageal squamous cell neoplasms in 25 enrolled patients were treated by endoscopic submucosal dissection. The therapeutic efficacy, complications, and follow-up results were assessed.
RESULTS
The mean size of the lesions was 21 ± 13 mm (range 2-55 mm); the mean size of the resection specimens was 32 ± 12 mm (range 10-70 mm). The en block resection rate was 100% (27/27), and en block resection with tumor-free lateral/basal margins was 88.9% (24/27). Perforation occurred in 1 patient who was managed by conservative medical treatments. None of the patients developed local recurrence or distant metastasis in the follow-up period.
CONCLUSION
Endoscopic submucosal dissection is applicable to superficial esophageal squamous cell neoplasms with promising results.
摘要
目的
评估内镜黏膜下剥离术治疗浅表性食管鳞状细胞肿瘤的疗效。
方法
2007年7月至2009年3月期间，对25例入选患者的27个连续浅表性食管鳞状细胞肿瘤进行了内镜黏膜下剥离术治疗。评估了治疗效果、并发症及随访结果。
结果
病变的平均大小为21±13毫米（范围2 - 55毫米）；切除标本的平均大小为32±12毫米（范围10 - 70毫米）。整块切除率为100%（27/27），切缘无肿瘤的整块切除率为88.9%（24/27）。1例患者发生穿孔，经保守药物治疗。随访期间无患者发生局部复发或远处转移。
结论
内镜黏膜下剥离术适用于浅表性食管鳞状细胞肿瘤，效果良好。
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