Department of Gastroenterology, the Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, P.R. China; Drum Tower Hospital, Medical School of Nanjing University, Nanjing, P.R. China.
Department of Gastroenterology, the Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, P.R. China.
United European Gastroenterol J. 2016 Apr;4(2):242-9. doi: 10.1177/2050640615604780. Epub 2015 Sep 7.
Little is known about the outcomes of endoscopic submucosal dissection in elderly patients with superficial squamous esophageal neoplasms.
To assess the efficacy and safety of endoscopic submucosal dissection for superficial squamous esophageal neoplasms in elderly patients (≥65 years) compared with non-elderly patients.
All patients with superficial squamous esophageal neoplasms receiving endoscopic submucosal dissection were retrospectively analyzed. Among them, 130 were aged 65 or older (group A), and 201 were aged younger than 65 years (group B). Therapeutic efficacy, adverse events, and follow-up data were evaluated.
Group A had a higher prevalence of concomitant diseases than group B (52.3% vs. 14.9%, respectively). R0 resection rate was 82.3% in group A and 84.6 % in group B (P = 0.717). The curative resection rate was 80.8% in group A and 83.6% in group B (P = 0.653). The rate of procedure-related non-cardiopulmonary adverse events was 20.8% in group A and 16.9% in group B (P = 0.377). The incidence of cardiopulmonary adverse events during or after the procedure was 6.2% in group A and 2.5% in group B (P = 0.094). No procedure-related mortality was reported in either group.
Endoscopic submucosal dissection is effective and safe for treating superficial squamous esophageal neoplasms in elderly patients.
对于老年患者（≥65 岁）的表浅性食管鳞状上皮肿瘤，内镜黏膜下剥离术的疗效和安全性知之甚少。
评估内镜黏膜下剥离术治疗老年（≥65 岁）与非老年患者表浅性食管鳞状上皮肿瘤的疗效和安全性。
回顾性分析所有接受内镜黏膜下剥离术治疗的表浅性食管鳞状上皮肿瘤患者。其中年龄≥65 岁者 130 例（A 组），年龄<65 岁者 201 例（B 组）。评估治疗效果、不良事件和随访数据。
A 组合并症的发生率高于 B 组（分别为 52.3%和 14.9%）。A 组 R0 切除率为 82.3%，B 组为 84.6%（P=0.717）。A 组的完全切除率为 80.8%，B 组为 83.6%（P=0.653）。A 组与 B 组术中及术后与操作相关的非心肺不良事件发生率分别为 20.8%和 16.9%（P=0.377）。A 组术中及术后心肺不良事件的发生率为 6.2%，B 组为 2.5%（P=0.094）。两组均未发生与操作相关的死亡。
内镜黏膜下剥离术治疗老年患者表浅性食管鳞状上皮肿瘤是有效且安全的。
