Ramesh L Londonkar, Department of Studies and Research in Biotechnology, Gulbarga University Gulbarga 585106, Karnataka, India.
World J Gastrointest Oncol. 2009 Oct 15;1(1):82-8. doi: 10.4251/wjgo.v1.i1.82.
To examine the antiulcerogenic effects of various extracts of Mentha arvensis Linn on acid, ethanol and pylorus ligated ulcer models in rats and mice.
Various crude extracts of petroleum ether, chloroform, or aqueous at a dose of 2 g/kg po did not produce any signs or symptoms of toxicity in treated animals. In the pyloric ligation model oral administration of different extracts such as petroleum ether, chloroform and aqueous at 375 mg/kg po, standard drug ranitidine 60 mg/kg po and control group 1% Tween 80, 5 mL/kg po to separate groups of Wister rats of either sex (n = 6) was performed. Total acidity, ulcer number, scoring, incidence, area, and ulcer index were assessed.
There was a decrease in gastric secretion and ulcer index among the treated groups i.e. petroleum ether (53.4%), chloroform (59.2%), aqueous (67.0%) and in standard drug (68.7%) when compared to the negative control. In the 0.6 mol/L HCl induced ulcer model in rats (n = 6) there was a reduction in ulcerative score in animals receiving petroleum ether (50.5%), chloroform (57.4%), aqueous (67.5%) and standard. drug (71.2%) when compared to the negative control. In the case of the 90% ethanol-induced ulceration model (n = 6) in mice, there was a decrease in ulcer score in test groups of petroleum ether (53.11%), chloroform (62.9%), aqueous (65.4%) and standard drug ranitidine (69.7%) when compared to the negative control. It was found that pre-treatment with various extracts of Mentha arvensis Linn in three rat/mice ulcer models ie ibuprofen plus pyloric ligation, 0.6 mol/L HCl and 90% ethanol produced significant action against acid secretion (49.3 ± 0.49 vs 12.0 ± 0.57, P < 0.001). Pre-treatment with various extracts of Mentha arvensis Linn showed highly -significant activity against gastric ulcers (37.1 ± 0.87 vs 12.0 ± 0.57, P < 0.001).
Various extracts of Mentha arvensis Linn. 375 mg/kg body weight clearly shows a protective effect against acid secretion and gastric ulcers in ibuprofen plus pyloric ligation, 0.6 mol/L HCl induced and 90% ethanol-induced ulcer models.
研究薄荷（Mentha arvensis Linn）的各种提取物对大鼠和小鼠酸、乙醇和幽门结扎溃疡模型的抗溃疡作用。
给予不同剂量（2 g/kg po）的石油醚、氯仿或水的各种粗提取物，未在治疗动物中产生任何毒性迹象或症状。在幽门结扎模型中，将不同提取物（如石油醚、氯仿和水）以 375 mg/kg po、标准药物雷尼替丁 60 mg/kg po 和对照组 1%吐温 80、5 mL/kg po 分别口服给予每组雄性和雌性 Wister 大鼠（n = 6）。评估总酸度、溃疡数、评分、发生率、面积和溃疡指数。
与阴性对照组相比，各治疗组（石油醚 53.4%、氯仿 59.2%、水 67.0%和标准药物 68.7%）的胃分泌和溃疡指数均降低。在大鼠 0.6 mol/L HCl 诱导的溃疡模型中（n = 6），与阴性对照组相比，接受石油醚（50.5%）、氯仿（57.4%）、水（67.5%）和标准药物的动物的溃疡性评分降低。在小鼠 90%乙醇诱导的溃疡模型中（n = 6），与阴性对照组相比，石油醚（53.11%）、氯仿（62.9%）、水（65.4%）和标准药物雷尼替丁（69.7%）的治疗组的溃疡评分降低。结果表明，在三种大鼠/小鼠溃疡模型（即布洛芬加幽门结扎、0.6 mol/L HCl 和 90%乙醇）中，薄荷各种提取物的预处理对胃酸分泌产生了显著作用（49.3 ± 0.49 与 12.0 ± 0.57，P < 0.001）。薄荷各种提取物预处理对胃溃疡表现出高度显著的活性（37.1 ± 0.87 与 12.0 ± 0.57，P < 0.001）。
薄荷 375 mg/kg 体重的各种提取物明显显示出对布洛芬加幽门结扎、0.6 mol/L HCl 诱导和 90%乙醇诱导溃疡模型中胃酸分泌和胃溃疡的保护作用。
