Ahlem Lahmar, Sabah Mzabi-Regaya, Department of Pathology, Mongi Slim Hospital, 2046 Sidi-Daoued La Marsa, Tunis, Tunisia.
World J Gastrointest Surg. 2010 Apr 27;2(4):143-6. doi: 10.4240/wjgs.v2.i4.143.
Pancreaticobiliary maljunction is a congenital anomaly in which the junction between the pancreatic duct and the common bile duct is located outside the sphincter of Oddi. It is well known that pancreaticobiliary maljunction is frequently associated with carcinoma of thebiliary tract. We report a case of metachronous cancer of the gallbladder and pancreas associated with pancreaticobiliary maljunction and cystic dilatation of common bile duct in a 68-year-old Tunisian woman who underwent a cholecystectomy for acute cholecystitis. The pancreatic tumor was an adenosquamous carcinoma. Pancreaticobiliary maljunction allows for pancreatobiliary or biliopancreatic reflux which may induce biliary tract carcinoma. Few cases of multifocal cancer associated with this anomaly have been reported. The association with pancreatic carcinoma remains rare. Close attention should be given to both the biliary tract system and pancreas during the long-term follow-up of patients with pancreaticobiliary maljunction, especially after they have undergone a choledochojejunostomy.
胰胆管合流异常是一种先天性异常，其特征为胰管与胆总管的连接处位于奥狄括约肌之外。众所周知，胰胆管合流异常常与胆道癌相关。我们报告了 1 例 68 岁突尼斯女性病例，该患者因急性胆囊炎行胆囊切除术，术后发现胰胆管合流异常伴胆总管囊性扩张，且先后发生胆囊和胰腺的异时性癌。胰肿瘤为腺鳞癌。胰胆管合流异常导致胰胆或胆胰反流，可能引发胆道癌。已有少数关于该异常相关多灶性癌的报道。与胰胆管合流异常相关的胰腺癌仍然较为罕见。对于胰胆管合流异常患者，尤其是行胆肠吻合术的患者，应在长期随访中密切关注胆道系统和胰腺，以防癌变。
