丙型肝炎病毒与外周血单个核细胞储存库 帕特里夏·巴雷
Hepatitis C virus and peripheral blood mononuclear cell reservoirs Patricia Baré.
作者信息
Baré Patricia
机构信息
Patricia Baré, Virology Laboratory, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires 1425, Argentina.
出版信息
World J Hepatol. 2009 Oct 31;1(1):67-71. doi: 10.4254/wjh.v1.i1.67.
Abstract
The existence of hepatitis C virus (HCV) infection in extrahepatic sites has been widely demonstrated. Since peripheral blood mononuclear cells have been the most investigated, compelling evidence of an association with HCV has been shown. Different studies have revealed that HCV RNA can persist and replicate in immune cells but the relevance of its presence and persistence over time is still unknown. As the contribution of this extrahepatic reservoir could have several clinical implications in viral transmission, treatment response and disease pathogenesis, future studies are required to improve our knowledge of the extrahepatic manifestations of HCV and its possible consequences.
摘要
丙型肝炎病毒（HCV）在肝外部位感染的存在已得到广泛证实。由于外周血单核细胞是研究最多的，已显示出与HCV相关的有力证据。不同的研究表明，HCV RNA可在免疫细胞中持续存在并复制，但其随时间存在和持续的相关性仍不清楚。由于这种肝外病毒库的作用可能在病毒传播、治疗反应和疾病发病机制方面产生多种临床影响，因此需要未来的研究来提高我们对HCV肝外表现及其可能后果的认识。
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