Department of Emergency, Affiliated Hospital, Guiyang Medical College, Guiyang City, Guizhou Province, China.
Neurocrit Care. 2011 Feb;14(1):118-26. doi: 10.1007/s12028-010-9473-8.
To observe the effects of the minimally invasive removal of an intracerebral hematoma on the glutamate concentration, blood-brain barrier (BBB) permeability and brain water content in the brain tissue surrounding the hematoma and to provide a theoretical basis for minimally invasive removal of intracerebral hematomas.
Thirty rabbits (2.8-3.4 kg body weight) were selected to establish a model of intracerebral hemorrhage, and they were randomly divided into a model control group and a minimally invasive group after the model was prepared successfully. The intracerebral hematoma was evacuated by stereotactic procedures in minimally invasive group 6 h after the model was established. The glutamate content, the permeability of the BBB and the brain water content in perihematomal brain tissues were determined and compared between the two groups.
The glutamate content, the permeability of the BBB and the brain water content in the perihematomal brain tissues were significantly decreased compared to the model control group 1, 3, and 7 days after the minimally invasive removal of the intracerebral hematoma.
Minimally invasive surgery for removal of an intracerebral hematoma could significantly reduce the glutamate content, BBB permeability and the brain water content in perihematomal brain tissues.
观察微创清除颅内血肿对血肿周围脑组织中谷氨酸浓度、血脑屏障（BBB）通透性和脑含水量的影响，为微创清除颅内血肿提供理论依据。
选择 30 只（体重 2.8-3.4kg）兔建立颅内血肿模型，成功制备模型后随机分为模型对照组和微创组。微创组在模型建立后 6h 行立体定向手术清除颅内血肿。测定并比较两组血肿周围脑组织中谷氨酸含量、BBB 通透性和脑含水量。
与模型对照组比较，微创清除颅内血肿后 1、3、7d 血肿周围脑组织中谷氨酸含量、BBB 通透性和脑含水量均明显降低。
微创清除颅内血肿可显著降低血肿周围脑组织中谷氨酸含量、BBB 通透性和脑含水量。
