Hester Robert, Lubman Dan I, Yücel Murat
Department of Psychology, University of Melbourne, Melbourne, VIC, 3010, Australia.
Curr Top Behav Neurosci. 2010;3:301-18. doi: 10.1007/7854_2009_28.
Recent neurobiological models propose that executive control deficits play a critical role in the development and maintenance of drug addiction. In this review, we discuss recent advances in our understanding of executive control processes and their constituent neural network, and examine neuropsychological and neuroimaging evidence of executive control dysfunction in addicted drug users. We explore the link between attentional biases to drug-related stimuli and treatment outcome, and discuss recent work demonstrating that the hedonic balance between drug cues and natural reinforcers is abnormal in addiction. Finally, we consider the potential impact of early drug use on the developing adolescent brain, and discuss research examining premorbid executive control impairments in drug-naïve "at-risk" populations.
最近的神经生物学模型表明，执行控制缺陷在药物成瘾的发展和维持中起着关键作用。在这篇综述中，我们讨论了我们对执行控制过程及其组成神经网络理解的最新进展，并研究了成瘾药物使用者执行控制功能障碍的神经心理学和神经影像学证据。我们探讨了对与药物相关刺激的注意偏向与治疗结果之间的联系，并讨论了最近的研究，这些研究表明在成瘾中药物线索与自然强化物之间的享乐平衡是异常的。最后，我们考虑早期药物使用对发育中的青少年大脑的潜在影响，并讨论对未使用过药物的“高危”人群病前执行控制损伤的研究。
