Ma Guan-sheng, Ji Cheng-ye, Ma Jun, Mi Jie, Sung Rita yt, Xiong Feng, Yan Wei-li, Hu Xiao-qi, Li Yan-ping, DU Song-ming, Fang Hong-yun, Jiang Jing-xiong
National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2010 Jun;31(6):609-15.
To explore the optimal threshold values of waist circumference (WC) in detecting the risk on cardiovascular (CV) among the Chinese children and adolescents.
Association of WC and CV risk factors were studied among 65 898 children and adolescents aged 7 - 18 years whose data were pooled from nine studies carried out in China. Receive-operating characteristic analysis (ROC) and logistic regression were employed to derive optimal age- and sex-specific waist circumference references for predicting the CV risk factors.
A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population, while a remarkable increasing trend occurred from the 90th percentile. The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls, and at the 90th percentiles it could detect at least two of the above three CV risk factors. In comparison with children whose waist circumference was below the 75th percentile, the odds ratio of two CV risk factors doubled among children with waist circumference between 75th and 90th percentile, and increased by 6 times among children with waist circumference above the 90th percentile. The trend of high blood pressure increasing remained significant with waist circumference after having been stratified by BMI category.
The 75th and the 90th percentile of WC appeared to be the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents.
探讨中国儿童和青少年中腰围（WC）用于检测心血管疾病（CV）风险的最佳阈值。
对65898名7至18岁的儿童和青少年进行研究，其数据来自在中国开展的9项研究，分析腰围与心血管疾病风险因素之间的关联。采用受试者工作特征分析（ROC）和逻辑回归来得出预测心血管疾病风险因素的最佳年龄和性别特异性腰围参考值。
在研究人群中，从腰围的第75百分位数开始观察到心血管疾病风险因素有轻微上升趋势，而从第90百分位数开始出现显著上升趋势。预测高血压的最佳腰围阈值，男孩和女孩均为第75百分位数，在第90百分位数时可检测到上述三种心血管疾病风险因素中的至少两种。与腰围低于第75百分位数的儿童相比，腰围在第75至第90百分位数之间的儿童出现两种心血管疾病风险因素的比值比翻倍，腰围高于第90百分位数的儿童则增加了6倍。按BMI类别分层后，高血压随腰围增加的趋势仍然显著。
腰围的第75和第90百分位数似乎是预测中国儿童和青少年心血管疾病因素风险增加和大幅增加的最佳切点。
