Sun Xiaoshi, Li Tianlian, Tian Yumeng, Ren Shuying, Li Ling, Li Ping
Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Dec 15;15:3913-3922. doi: 10.2147/DMSO.S388620. eCollection 2022.
We investigated the association of omentin with metabolic syndrome (MetS), MetS components, and obesity in adolescents.
A total of 742 middle-school students from Liaoyang City were enrolled in this cross-sectional study using the stratified cluster sampling method. Clinical information and blood samples were collected, and serum omentin levels were measured using enzyme-linked immunosorbent assay.
Mean plasma omentin levels were lower in male than in female participants (88.25 (interquartile range 63.02-133.61) vs 99.46 (interquartile range 69.08-188.35) ng/L, = 0.004). The participants were divided into four groups according to the quartile (Q) values of omentin from low to high. With increasing omentin levels from Q1 to Q4, the age of adolescents and the proportion of males gradually increased ( < 0.05), whereas the body mass index (BMI) ( < 0.05) and prevalence of MetS ( > 0.05) tended to decrease. Omentin levels were significantly and negatively correlated with waist circumference and BMI (correlation coefficients of -0.099 and -0.115, respectively). Regression analysis showed that omentin level was independently associated with the risk of MetS (Odds ratio, OR = 0.639, 95% confidence interval, CI (0.432, 0.945)), which was attributed to the association with central obesity (OR = 0.775, 95% CI (0.605, 0.993)) among MetS components. Increased omentin levels also indicated a reduced risk of obesity (OR = 0.700, 95% CI (0.563, 0.870)).
Omentin is an independent predictor of MetS and obesity among adolescents in northeast China.
我们研究了网膜素与青少年代谢综合征（MetS）、MetS各组分及肥胖之间的关联。
采用分层整群抽样方法，对来自辽阳市的742名中学生进行了这项横断面研究。收集临床信息和血样，采用酶联免疫吸附测定法检测血清网膜素水平。
男性参与者的血浆网膜素平均水平低于女性（88.25（四分位间距63.02 - 133.61）对99.46（四分位间距69.08 - 188.35）ng/L，P = 0.004）。根据网膜素的四分位数（Q）值由低到高将参与者分为四组。随着网膜素水平从Q1升高到Q4，青少年的年龄和男性比例逐渐增加（P < 0.05），而体重指数（BMI）（P < 0.05）和MetS患病率（P > 0.05）呈下降趋势。网膜素水平与腰围和BMI显著负相关（相关系数分别为 - 0.099和 - 0.115）。回归分析表明，网膜素水平与MetS风险独立相关（比值比，OR = 0.639，95%置信区间，CI（0.432，0.945）），这归因于与MetS各组分中的中心性肥胖相关（OR = 0.775，95% CI（0.605，0.993））。网膜素水平升高也表明肥胖风险降低（OR = 0.700，95% CI（0.563，0.870））。
网膜素是中国东北地区青少年MetS和肥胖的独立预测因子。
